局解手术学杂志2016，Vol.25Issue(12)：863-866,867,5.DOI:10.11659/jjssx.08E016052
头颈部鳞癌中TP53基因的调控网络分析
TP53-related gene regulatory network analysis on head and neck squamous carcinoma
摘要
Abstract
Objective To find out the TP53-related mechanism underlying head and neck squamous cell carcinoma.Methods We used cbioportal to analyse the expression of TP53 and identify the co-expressed genes of TP53 in 279 samples from head and neck squamous cell carcinoma in TCGA database.We used String and DAVID database to establish the co-expression network of TP53 and analyze its func-tion.We used lncRNA2target and StarBase database to screen the microRNA,lncRNA and ceRNA that regulate TP53.Finally,Cytoscape soft-ware was used to establish TP53-related ceRNA network.Results In the 279 samples,77%samples were abnormal expression,and the sur-vival rate of patients with abnormal expression of TP53 was significantly lower than that of normal expression of TP53.Besides,we found 288 TP53-related co-expressed gene.(Spearman score and Pearson score>0.3)The functions of these genes were mainly transcription regulation, cell apoptosis,propagation and immune response.Gene regulatory network revealed that 43 microRNAs (i.g.,has-miR-186-5p and has-miR-202-3p),6 lncRNAs (e.g.,MEG1,TUG1 and MALAT1)and 56 ceRNAs (e.g.,PHC2,FZD4 and TUB)could regulate TP53.Conclusion We established TP53-related gene regulatory network and identified microRNA,lncRNA and ceRNA that regulate TP53.The data generated from this study could provide a new pointcut in research and treatment of head and neck squamous cell carcinoma.关键词
喉鳞状细胞癌/TP53/长链非编码RNA/竞争性内源性RNAKey words
laryngeal squamous cell carcinoma/TP53/lncRNA/ceRNA分类
医药卫生引用本文复制引用
徐明义,郑艳秋,孙娟,胡文良,王亚平,崔晓波,李玲香..头颈部鳞癌中TP53基因的调控网络分析[J].局解手术学杂志,2016,25(12):863-866,867,5.基金项目
内蒙古医科大学科技百万工程项目 （）
