局解手术学杂志2016，Vol.25Issue(12)：871-874,4.DOI:10.11659/jjssx.06E016008
bFGF改善白内障手术引发角膜内皮损伤
Effect of basic fibroblast growth factor on corneal endothelial cell damage after cataract surgery
摘要
Abstract
Objective To explore the effect of basic fibroblast growth factor (bFGF)on corneal endothelial cell damage after cataract surgery.Methods Thirty rabbits (60 eyes)whose lens extraction were done by phacoemulsification were divided into 2 groups,namely,bF-GF treatment group and control group.bFGF ophthalmic gel was used to treat the eyes 3 times daily in bFGF treatment group,and the saline of the same volume was used to treat the eyes in control group.The time of corneal edema subsidence was recorded;the healing area of inci-sion,corneal thickness,the density of corneal endothelial cells and the NO,IL-1 ,IL-6 and TNF-αcontents of the aqueous sample in anterior chamber were measured.Results The time of corneal edema subsidence of bFGF treatment group decreased significantly compared with con-trol group;bFGF treatment accelerated the healing rate of incision,the recovery of corneal thickness and the density of corneal endothelial cells and the decrease of the NO,IL-1 IL-6 and TNF-αcontents of the aqueous sample in anterior chamber.Conclusion bFGF treatment can accelerate the recovery of the corneal endothelial cell damage,which was induced by cataract surgery.关键词
白内障手术/碱性成纤维细胞生长因子/角膜内皮损伤/角膜内皮细胞密度Key words
cataract surgery/basic fibroblast growth factor/endothelial cell damage/the density of corneal endothelial cells分类
医药卫生引用本文复制引用
孙丹宇,包赫,姜仕先..bFGF改善白内障手术引发角膜内皮损伤[J].局解手术学杂志,2016,25(12):871-874,4.基金项目
黑龙江省卫生厅2014年科学研究专项项目 （）
