中国现代医学杂志2016，Vol.26Issue(22)：34-37,4.DOI:10.3969/j.issn.1005-8982.2016.22.007
尿Smad1与2型糖尿病肾病早期诊断及病情进展关系的探讨
Relationship of urinary Smad1 with early diagnosis and progression of diabetic nephropathy in type 2 diabetes patients
李巧 1李佳萦 2冯烈 2万晓刚 1朱章志1
作者信息
- 1. 广州中医药大学第一附属医院 内分泌科，广东 广州 510405
- 2. 暨南大学第一附属医院 内分泌科，广东 广州 510632
- 折叠
摘要
Abstract
Objective To explore the relationship of urinary Smad1 with early diagnosis and progression of diabetic nephropathy in type 2 diabetes patients. Methods In this study 166 subjects with type 2 diabetes and 80 healthy volunteers were enrolled. The patients were divided into three groups according to urine albumin to creatinine ratio, i.e. normal albuminuria group, microalbuminuria group and macroalbuminuria group. The 80 healthy volunteers were the controls. Enzyme-linked immunosorbent assay was used to detect the urinary Smad1 concentration. Urinary Smad1 to creatinine ratio (SCR) was used as the standard reference. Results The SCR in the microalbuminuria group was higher than that in the normal albuminuria group ( < 0.05). SCR of the macroalbuminuria group was higher than that of the microalbuminuria group ( < 0.05), while there was no difference between the normal albuminuria group and controls ( > 0.05). Pearson correlation analysis showed that SCR was positively correlated to HbA1c, duration and diabetic retinopathy of the disease ( = 0.384, 0.413 and 0.325; = 0.000, 0.005 and 0.021, respectively). ROC curve showed that urinary Smad1 is a good indicator for early diagnosis of type 2 diabetic nephropathy. Conclusions Urinary Smad1 may be a new early diagnostic indicator for diabetic nephropathy andcould reflect the progression of diabetic nephropathy.关键词
尿Smad1/糖尿病肾病/尿微量白蛋白与肌酐比值Key words
urinary smad1/diabetic nephropathy/SCR分类
医药卫生引用本文复制引用
李巧,李佳萦,冯烈,万晓刚,朱章志..尿Smad1与2型糖尿病肾病早期诊断及病情进展关系的探讨[J].中国现代医学杂志,2016,26(22):34-37,4.
