中国现代医学杂志2016，Vol.26Issue(22)：50-53,4.DOI:10.3969/j.issn.1005-8982.2016.22.011
胎儿鼻骨、颈项透明层厚度与母体血清学检测联合筛查唐氏综合征
Joint measurement of fetal nasal bone and nuchal translucency and maternal serological test for identification of Down's syndrome
朱继红 1文珂1
作者信息
- 1. 河南大学淮河医院 超声科，河南 开封 475000
- 折叠
摘要
Abstract
Objective To discuss the value of ultrasonic measurement of fetal nasal bone (NB) and nuchal translucency (NT) thickness during the first trimester of pregnancy and maternal AFP and free-β-HCG detection during the second trimester of pregnancy in identifying Down's syndrome (DS). Methods A total of 2,185 pregnant women in the outpatient and inpatient departments from March 2010 to June 2014 were selected. The NB and the thickness of NT were detected by ultrasound from the 11th to 14th gestational week. The absence of nasal bone was abnormal and NT≥3 mm was designed as high risk. The levels of maternal serum AFP and free-β-HCG were detected from the 15th to 21st gestational week. The risk of DS was assessed by the software of analysis system of DS prenatal screening, and the risk rate ≥1/270 was designed as high risk. Amniotic membrane puncture was performed for chromosome examination of amniotic fluid cells under informed consent. The screening results were compared among group A (NB+NT), group B (NB+maternal serological test) and group C (NB+NT+maternal serological test). Results The incidence of DS in the group C was significantly higher than that of the groups A and B ( < 0.05). Conclusions The joint measurement of NB+NT+maternal serological test can improve the reliability of prenatal screening for DS, and improve the pertinence of invasive amniocentesis.关键词
唐氏综合征/胎儿鼻骨/颈项透明层厚度/血清学检测/联合筛查Key words
Down's syndrome/nasal bone/thickness of nuchal translucency/serological test/joint measurement分类
医药卫生引用本文复制引用
朱继红,文珂..胎儿鼻骨、颈项透明层厚度与母体血清学检测联合筛查唐氏综合征[J].中国现代医学杂志,2016,26(22):50-53,4.
