中国现代医学杂志2016，Vol.26Issue(22)：59-63,5.DOI:10.3969/j.issn.1005-8982.2016.22.013
瑞舒伐他汀联合荷丹片治疗急性脑梗死及对Copeptin、NT-proBNP水平变化研究
Rosuvastatin combined with Hedan tablets in treatment of acute cerebral infarction and effect on levels of copeptin and NT-proBNP
李彦玲 1郭华 2李艾帆 1张杰文3
作者信息
- 1. 郑州市第一人民医院 神经内科，河南 郑州 450004
- 2. 河南科技大学第一附属医院 影像科，河南 洛阳 471003
- 3. 郑州大学附属人民医院 神经内科，河南 郑州 450000
- 折叠
摘要
Abstract
Objective To study the effect of Rosuvastatin combined Hedan tablets on treatment of acute cerebral infarction and its influence on the levels of copeptin and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods Ninety-three patients with acute cerebral infarction treated in our hospital from March 2013 to April 2015 were divided into treatment group and control group according to the random number table. The control group received Rosuvastatin tablets, the treatment group was treated with Rosuvastatin and Hedan tablets. Results There was no significant difference in the total effective rate between the two groups (χ2= 2.461, = 0.117). The level of LDL-C in the treatment group was significantly lower than that in the control group ( =2.318, = 0.023), and the The level of HDL-C in the treatment group was significantly higher than that in the control group ( = 2.784, =0.007). The rate of the patients with standard LDL-C level in the treatment group was significantly higher than that in the control group (χ2 = 4.301, = 0.038). The total incidence of adverse reactions in the control group was significantly higher than that in the treatment group (χ2=4.301, = 0.038). After treatment, the copeptin and NT-proBNP levels in the treatment group were significantly lower than those in the control group ( < 0.05). Conclusions Rosuvastatin combined Hedan tablets has similar clinical curative effect to large dose of Rosuvastatin in treatment of acute cerebral infarction, but its total incidence of adverse reactions is significantly reduced, and has higher security. At the same time, it maybe improve the prognosis of patients.关键词
瑞舒伐他汀/荷丹片/急性脑梗死/Copeptin/N端脑钠肽原Key words
Rosuvastatin/Hedan tablet/acute cerebral infarction/copeptin/N-terminal pro-brain natriuretic peptide分类
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李彦玲,郭华,李艾帆,张杰文..瑞舒伐他汀联合荷丹片治疗急性脑梗死及对Copeptin、NT-proBNP水平变化研究[J].中国现代医学杂志,2016,26(22):59-63,5.
