中国药房2016，Vol.27Issue(34)：4764-4766,4767,4.DOI:10.6039/j.issn.1001-0408.2016.34.04
蛇床子催眠活性组分对小鼠镇静催眠、学习记忆及宿醉反应的影响
Effects of Hypnotic Active Constituent of Cnidium monnieri on Sedation and Hypnosis,Learning and Mem-ory,Hangover of Mice
摘要
Abstract
OBJECTIVE:To study the effects of hypnotic active constituent of Cnidium monnieri(CHC)on sedation and hyp-nosis,learning and memory,hangover of mice. METHODS:60 mice were randomly divided into blank control group(2% Tween 80 solution),diazepam group (6 mg/kg) and CHC high-dose,medium-dose and low-dose groups (520,260,130 mg/kg),with 12 mice in each group. They were given relevant medicine intragastrically twice a day. The sleep latency and sleep duration,the times of autonomic activities and standing times after sleep,escape incubation period and the number of errors in step through test were observed in each group 1 d after medication. The place navigation test and spatial probe test were conducted 16 day after medi-cation. RESULTS:Compared with blank control group,sleep duration of mice was prolonged in diazepam group and CHC groups while standing times before and after sleep were decreased;in diazepam group,the number of errors was increased before sleep, while activity times was decreased after sleep;escape incubation period was prolonged,while target time was shortened;the ratio of target distance was decreased;escape incubation period of mice was prolonged in CHC high-dose group,with statistical signifi-cance (P<0.05 or P<0.01). Compared with diazepam group,sleep duration of mice was prolonged in CHC medium-dose and high-dose group,and activity times after sleep were increased;activity times before sleep were decreased in CHC low-dose group;the number of errors before sleep were decreased in CHC groups,with statistical significance (P<0.05 or P<0.01). Compared with before sleep,escape incubation period of blank control group was prolonged;activity times after sleep of CHC groups were in-creased while standing times after sleep were decreased;escape incubation period after sleep was prolonged (except for medi-um-dose group),with statistical significance (P<0.05 or P<0.01). There was no statistical significance in other indexes (P>0.05). CONCLUSIONS:CHC shows sedation and hypnotic effect in mice,but has no effect on learning and memory and doesn’t induce hangover response.关键词
蛇床子/催眠活性组分/镇静催眠/学习记忆/宿醉反应Key words
Cnidium monnieri/Hypnotic active constituent/Sedation and hypnosis/Learning and memory/Hangover分类
医药卫生引用本文复制引用
马澜,仝立国,宋美卿,胡文卓,贾力莉,牛艳艳,仲启明,冯玛莉..蛇床子催眠活性组分对小鼠镇静催眠、学习记忆及宿醉反应的影响[J].中国药房,2016,27(34):4764-4766,4767,4.基金项目
国家自然科学基金面上项目（No.81173574）；山西省实验动物专项资金项目[No.2013（K05）] （）
