中国药房2016，Vol.27Issue(34)：4770-4773,4.DOI:10.6039/j.issn.1001-0408.2016.34.06
pH对吲哚美辛理化性质和离体透皮参数的影响
Effects of pH Value on Physicochemical Property and in vitro Transdermal Parameters of Indomethacin
摘要
Abstract
OBJECTIVE:To study effects of different pH values on physicochemical property and in vitro transdermal parame-ters of indomethacin. METHODS:HPLC method was used for quantitative analysis;solubility,apparent partition coefficient(Kapp) and in vitro transdermal parameters [permeation rate(Js)and 4,12,24 h accumulative premeation amount(Q4 h,Q12 h,Q24 h)] of In-domethacin gel were determined at pH 5.0,5.8,6.5,7.3,8.0. The multiple correlation analysis and regression model were used to determine the correlations of pH,solubility,Kapp and transdermal parameters. RESULTS:Indomethacin gel in vitro transdermal model fully complied with zero-order kinetic model;and pH was good linear relationship with solubility and Kapp(r≥0.892 0),show-ing good correlation(r≥0.968 0);the exponential model relationships were shown among pH,solubility,Kapp and in vitro transder-mal parameters;using pH 7.3 as the critical point,corresponding Kapp was equal to 3.34. CONCLUSIONS:Adjusting pH can im-prove the solubility and Kapp of indomethacin;adjusting existing form of molecular ion can increase Q and Js of indomethacin.关键词
pH/吲哚美辛/理化性质/离体透皮参数/相关性Key words
pH/Indomethacin/Physicochemical property/in vitro transdermal parameters/Correlation分类
医药卫生引用本文复制引用
张永萍,徐剑,吴静澜,谢伟杰..pH对吲哚美辛理化性质和离体透皮参数的影响[J].中国药房,2016,27(34):4770-4773,4.基金项目
贵州省高层次创新型人才培养项目 （）
