中国药房2016，Vol.27Issue(34)：4774-4776,3.DOI:10.6039/j.issn.1001-0408.2016.34.07
益气活血风静胶囊对麻醉犬脑血流量和脑血管阻力的影响
Effects of Yiqi Huoxue Fengjing Capsules on Cerebral Blood Flow and Cerebral Vascular Resistance in Anesthetized Dogs
摘要
Abstract
OBJECTIVE:To observe the effects of Yiqi huoxue fengjing capsules on the cerebral blood flow(CBF)and cere-bral vascular resistance (CVR) in anesthetized dogs. METHODS:18 Beagle dogs were randomly divided into sham operation group(purified water),positive control TCM group [Naoxintong capsules,0.3 g(crude drug)/kg],positive control pharmaceutical chemicals group (nimodipine,7 × 10-3 g/kg) and Yiqi huoxue fengjing capsules low-dose,medium-dose and high-dose groups [0.63,1.26,2.52 g(crude drug)/kg)],with 3 dogs in each group. They were given relevant medicine via duodenum. CBF,CVR, blood pressure and heart rate of the dogs were measured before medication and 30,60,120 min after medication. RESULTS:30, 60,120 min after medication,CBF increased in positive control TCM group,positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsule high-dose group,while CVR decreased significantly in positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsules high-dose group,blood pressure and heart rate of positive control pharmaceutical chemi-cals group decreased,with statistical significance compared to sham operation group(P<0.05 or P<0.01). CONCLUSIONS:Yiqi huoxue fengjing capsules can increase CBF and decrease CVR,and they have no effect on blood pressure and heart rate in anesthe-tized dogs.关键词
益气活血风静胶囊/脑血流量/脑血管阻力/Beagle犬Key words
Yiqi huoxue fengjing capsules/Cerebral blood flow/Cerebral vascular resistance/Beagle dog分类
医药卫生引用本文复制引用
张军霞,林红军,张婷婷,陈炜,李振国,周继春..益气活血风静胶囊对麻醉犬脑血流量和脑血管阻力的影响[J].中国药房,2016,27(34):4774-4776,3.基金项目
河南省科技创新人才计划项目 （）
