中国药房2016，Vol.27Issue(34)：4797-4799,3.DOI:10.6039/j.issn.1001-0408.2016.34.14
阿苯达唑纳米微粉在大鼠体内的药动学研究
Pharmacokinetics Study of Albendazole Nano-powder in Rats
摘要
Abstract
OBJECTIVE:To study the pharmacokinetic change of albendazole (ABZ) in rats after nanocrystallization,and to lay a foundation for further study of ABZ nano-preparation. METHODS:16 rats were randomly divided into ABZ raw material (ABZ suspension)group and ABZ nano-powder(ABZ nano-powder suspension)group,with 8 rats in each group. They were giv-en relevant medicine 63 mg/kg intragastrically. 0.2-0.3 ml blood samples were collected from orbital cavity 0.5,1,2,4,8,12, 24,36,48,72 h after medication,respectively. Using mebendazole as internal standard,blood concentration of ABZ were deter-mined by RP-HPLC,and pharmacokinetics parameters were calculated by using 3p97 software. RESULTS:The pharmacokinetics of ABZ raw material and ABZ nano-powder in rats were in line with two-compartment model. The main pharmacokinetic parame-ters of ABZ raw material group vs. ABZ nano-powder group were as follows as cmax(3.20±1.41)μg/ml vs.(6.11±0.74)μg/ml;tmax (3.42±0.91)h vs.(3.15±0.27)h;AUC0-72 h(49.90±15.50)μg·h/ml vs.(78.36±8.78)μg·h/ml;AUC0-∞(52.30±10.10 )μg·h/ml vs.(80.27±8.26)μg·h/ml. Compared with ABZ raw material group,cmax,AUC0-72 h and AUC0-∞ of ABZ nano-powder group were increased significantly (P<0.05). CONCLUSIONS:The nanocrystallization of ABZ can enhance the absorbability rate and im-prove the absorption of drugs to some extent,and it also improves oral bioavailability of ABZ.关键词
阿苯达唑/纳米微粉/药动学/大鼠Key words
Albendazole/Nano-powder/Pharmacokinetics/Rats分类
医药卫生引用本文复制引用
马运芳,王建华,陈迹,任洁如..阿苯达唑纳米微粉在大鼠体内的药动学研究[J].中国药房,2016,27(34):4797-4799,3.基金项目
新疆包虫病重点实验室项目 （）
