中国药房2016，Vol.27Issue(34)：4817-4819,4820,4.DOI:10.6039/j.issn.1001-0408.2016.34.20
壮药痔疮熏洗液的止血、镇痛、抗炎和抗菌作用研究
Study on the Hemostasis,Analgesic,Anti-inflammatory and Anti-bacterial Effects of Zhuang Medicine Hemorrhoids Fumigant
摘要
Abstract
OBJECTIVE:To investigate the hemostasis,analgesic,anti-inflammatory and anti-bacterial effect of Zhuang medi-cine Hemorrhoids fumigant. METHODS:KM mice (or SD rats) were randomly divided into model control group,Compound schizonepeta lotion group [positive drug,0.56 g (crude drug)/kg] and Hemorrhoids fumigant low-dose,medium-dose and high-dose groups [2.40,4.80,9.60 g(crude drug)/kg] according to body mass,with 10 rats or mice in each group,for external admin-istration. The hemostasis,analgesic and anti-inflammation effects of Hemorrhoids fumigant were investigated through determining tail bleeding time,0.6% acetic acid-writhing times and xylene-induced ear swelling of mice and carrageenin-induced paw swelling of rats. The broth two times dilution method was used to determine minimal inhibitory concentration(MIC)and minimum bacteri-cidal concentration(MBC)of Hemorrhoids fumigant to Pseudomonas aeruginosa(PA),Staphylococcus epidermidis(SE),Esche-richia coli (EC),Monilia albicans (MA),Staphylococcus aureus (SA),Salmonella paratyphi B (SPB),Bacillus subtilis (BS) and Klebsiella pneumoniae (KP). RESULTS:Compared with model control group,the tail bleeding time,writhing times and the degree of ear swelling in mice were decreased in treatment groups,and the degree of paw swelling in rats was decreased in treat-ment groups,with statistical significance(P<0.05 or P<0.01). MIC of Hemorrhoids fumigant to PA,SE,EC,MA,SA,SPB, BS,KP were 0.045,0.091,0.091,0.181,0.091,0.091,0.091,0.181 g/ml,respectively;corresponding MBC were 0.091, 0.181,0.181,0.363,0.091,0.181,0.181,0.181 g/ml,respectively. CONCLUSIONS:Hemorrhoids fumigant shows obvious he-mostasis,analgesic,anti-inflammatory and anti-bacterial effects.关键词
痔疮熏洗液/止血/镇痛/抗炎/抗菌/大鼠/小鼠Key words
Hemorrhoids fumigant/Hemostasis/Analgesic/Anti-inflammatory/Anti-bacterial/Rat/Mice分类
医药卫生引用本文复制引用
黄一挚,黄明政,陈朝,孙平良,黄权芳,伍小燕..壮药痔疮熏洗液的止血、镇痛、抗炎和抗菌作用研究[J].中国药房,2016,27(34):4817-4819,4820,4.基金项目
广西卫生厅中医药科技专项课题 （）
