中国药房2016，Vol.27Issue(34)：4829-4832,4.DOI:10.6039/j.issn.1001-0408.2016.34.24
星点设计-响应面法优化血塞通滴丸成型工艺及冷凝液指纹图谱研究
Optimization of Molding Technology of Xuesaitong Dripping Pills by Central Composite Design-response Surface Method and Condensate Fingerprint Study
摘要
Abstract
OBJECTIVE:To optimize the forming technology of Xuesaitong drop pills,and to investigate the usable batche number of condensate oleum vaselini. METHODS:Taking the contents of Panax notoginseng saponins,ginsenoside Rg1 and no-toginsenoside R1,weight variation,appearance and quality score as index,single factor test and central composite design-response surface method were used to optimize dripper diameter,dripping distance,dripping temperature,the temperature of condensate up-per/lower layer. Using P. notoginseng saponins as control,the fingerprints of condensate were collected and compared after prepar-ing 15 batches of Xuesaitong drop pills (500 thousand pills per batch) continuously,and the usable batche number of condensate were investigated. RESULTS:The optimized molding technology of dripping pills was that the dripper diameter 3.9/5.1(inside/out-side,mm/mm),dripping distance 6 cm,dripping system temperature 80 ℃,the upper temperature of condensate 40 ℃,the lower temperature of condensate 10 ℃. Relative deviation of comprehensive score to predicted value were -1.37%,-1.71%,-1.51%for 3 batches,respectively. On retention time position of each component in P. notoginseng saponins fingerprint,corresponding peak was not found in the fingerprint of 15 batches of condensate. CONCLUSIONS:The optimized molding technology of Xue-saitong dripping pills is stable and available. Condensate liquid paraffin can be used to prepare 15 batches of Xuesaitong dripping pills at least.关键词
血塞通滴丸/三七总皂苷/成型工艺/制备/星点设计/响应面法/冷凝液/指纹图谱Key words
Xuesaitong dripping pills/Panax notoginseng saponins/Molding technology/Preparation/Central composite de-sign/Response surface method/Condensate/Fingerprint分类
医药卫生引用本文复制引用
屈云萍,蔡向杰,王娇,李菲,姜国志,陈钟,李振江..星点设计-响应面法优化血塞通滴丸成型工艺及冷凝液指纹图谱研究[J].中国药房,2016,27(34):4829-4832,4.基金项目
国家中医药管理局科技项目中药领域2013年度课题（No.国中医药科技发〔2013〕30号）；河北省科技计划项目 （）
