中国药房2016，Vol.27Issue(34)：4835-4837,4838,4.DOI:10.6039/j.issn.1001-0408.2016.34.26
通脉颗粒水提及制粒工艺优化
Optimization of Water Extraction and Granulating Techology of Tongmai Granule
摘要
Abstract
OBJECTIVE:To optimize water extraction and granulating technology of Tongmai granule. METHODS:Using the contents of notoginsenoside R1,ginsenoside Rg1,ginsenoside Re and ginsenoside Rb1 and yield of extracts as the index,L9(34)or-thogonal design was used to optimize and validate water extraction technology in preparation process of Tongmai granule. Decontam-ination,concentration and drying,diluent of granulating technology were investigated. RESULTS:The optimal water extraction technology was as follows as 8-fold water,soaking for 0.5 h,decocting 1.0 h each time,for 2 times. In validation test,the yield of extract was (28.38 ± 0.461)%(RSD=1.63%,n=3),and the content of total saponins was (5.029 ± 0.060) mg/g (RSD=1.20%,n=3). The optimized granulating technology was that extract was filtrated and decontaminated,and then concentrated un-der vacuum degree of 0.08 MPa and vacuum temperature of 60℃;the ratio of extraction powder-accessories(maltodextrin)was 3∶1,drying temperature was set at 85-90 ℃;the amount of diluent was 3%. Under this condition,the content of total saponins was (5.211 ± 0.207) mg/g (RSD=3.96%,n=3) . CONCLUSIONS:This technology is stable and feasible,and it is suitable for the preparation of Tongmai granule.关键词
通脉颗粒/水提工艺/制粒工艺/正交试验/喷雾干燥Key words
Tongmai granule/Water extraction technology/Granulating technology/Orthogonal test/Spray drying分类
医药卫生引用本文复制引用
尤文质,陈雪梅,苏娟娟,彭连共,管昌益..通脉颗粒水提及制粒工艺优化[J].中国药房,2016,27(34):4835-4837,4838,4.基金项目
福建省卫生厅中医科研项目 （）
