中国医学创新2016，Vol.13Issue(33)：1-4,4.DOI:10.3969/j.issn.1674-4985.2016.33.001
血浆炎症因子在首发脑卒中患者中的改变及其意义
The Change and Significance of Plasma Inflammatory Factors in Patients with Initial Stroke
摘要
Abstract
Objective:To investigate the changes of plasma inflammatory factors (hs-CRP,IL-6, TNF-α and Lp-PLA2) levels in patients with first stroke,and to evaluate the significance of the prediction of stroke.Method:101 patients with stroke in Dongguan Houjie Hospital from August 2014 to June 2015 were selected,and the same time,156 community-dwelling healthy controls were recruited as the control group.Blood glucose,blood lipids and plasma levels of inflammatory factors were detected,and the value of inflammatory cytokines in predicting the occurrence of stroke was evaluated by ROC curve.Result:The blood glucose in the case group was higher than that in the control group,the difference was statistically significant (P=0.000).The total cholesterol and high density lipoprotein levels of the two groups were compared,the differences were statistically significant(P=0.000).The levels of inflammatory factors,IL-6,TNF-α, Lp-PLA2 and hs-CRP in the two groups were compared,the differences were statistically significant(P=0.000). The area of ROC in the prediction of cerebral stroke was 0.850[95%CI(0.796,0.893)],the sensitivity was 80.5%,the specificity was 83.7%.Conclusion:The levels of plasma inflammatory cytokines in patients with first episode of stroke are significantly changed,the prediction model of inflammatory factors can effectively predict the occurrence of stroke.关键词
脑卒中/hs-CRP/IL-6/TNF-α/Lp-PLA2/风险预测模型Key words
Stroke/hs-CRP/IL-6/TNF-α/Lp-PLA2/Risk prediction model引用本文复制引用
黄晓芸,付文金,陈智昌,方浩威,王明霞,余映丽..血浆炎症因子在首发脑卒中患者中的改变及其意义[J].中国医学创新,2016,13(33):1-4,4.基金项目
东莞市社会科技发展基金资助 （）
