中国医学创新2016，Vol.13Issue(33)：13-15,16,4.DOI:10.3969/j.issn.1674-4985.2016.33.004
沙利度胺联合多西他赛对激素抵抗性前列腺癌患者的免疫功能影响
The Effect of Thalidomide Combined with Docetaxel on Immune Function in Patients with Hormone Refractory Prostate Cancer
尹卫华 1夏红梅 1罗小瑾 1徐荣 1胡小雄 1陈金平1
作者信息
- 1. 江西省宜春市人民医院 江西 宜春 330006
- 折叠
摘要
Abstract
Objective:To observe the effect of thalidomide combined with docetaxel on immunity of patients with hormone refractory prostate cancer.Method:48 patients diagnosed with hormone refractory prostate cancer were collected at the People’s Hospital of Yichun city from January 2010 to January 2015,they were randomly divided into two groups,24 cases in each group.The treatment group(Thalidomide combined with Docetaxel) and control group(Predisone combined with Docetaxel),the clinical effects,short-term adverse reaction,quality of life and improvement of immune function in the two groups were observed.Result:The clinical effect, quality of life and immune function of the treatment group improved significantly,and the side effects decreased significantly,there were significant differences compared to control group(P<0.05).The survival time of the treatment group than the control group, the difference was statistically significant (P=0.046).Conclusion:Thalidomide combined with Docetaxel effectively alleviate the progression of hormone refractory prostate cancer,Thalidomide can improve the patients immune system,reduce the side effect of chemotherapy,and obtain satisfactory effect,which is worth of popularizing.关键词
沙利度胺/多西他赛/激素抵抗性前列腺癌/免疫功能Key words
Thalidomide/Docetaxel/Hormone refractory prostate cancer/Immune function引用本文复制引用
尹卫华,夏红梅,罗小瑾,徐荣,胡小雄,陈金平..沙利度胺联合多西他赛对激素抵抗性前列腺癌患者的免疫功能影响[J].中国医学创新,2016,13(33):13-15,16,4.
