摘要
Abstract
Objective:To investigate the clinical effect of Lamivudine in the treatment of elderly patients with cirrhosis of the liver.Method:90 elderly patients with cirrhosis of the liver cirrhosis were randomly divided into observation group and control group,each of 45 cases.The control group was given conventional treatment,the observation group was given Lamivudine treatment based on the control group.Liver function and serum index of 6, 12,24 months were compared between the two groups before and after treatment.Result:The observation group after treatment of alanine aminotransferase (ALT),serum albumin (ALB),serum total bilirubin (TBIL) improved significantly better than those in control group(P<0.05).The HBV-DNA negative rate,HBeAg negative rate and HBeAg seroconversion rate of the observation group were significantly higher than those in control group(P<0.05). After two years of treatment,the Child-Pugh score of the observation group was significantly higher than that of the control group(P<0.05),the mortality rate of the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Lamivudine should be used in the treatment of patients with hepatitis B cirrhosis of the liver cirrhosis of the clinical effect is significant,can significantly inhibit the replication of HBV-DNA, improve liver function,alleviate the disease progress,it is worth clinical application.关键词
肝硬化/乙肝/失代偿期/老年/拉米夫定Key words
Liver cirrhosis/Hepatitis B/Compensatory period/Elderly/Lamivudine
