中国医学创新2016，Vol.13Issue(34)：19-22,4.DOI:10.3969/j.issn.1674-4985.2016.34.006
蛛网膜腔出血后脑组织氧自由基代谢的实验研究
Changes of Oxygen Free Radical Metabolism in Brain Tissues after Subarachnoid Hemorrhage in Rabbits
摘要
Abstract
Objective:To investigate the dynamical changes and significance of oxygen free radical metabolism in brain tissues after the experimental subarachnoid hemorrhage(SAH) in rabbits.Method:24 white rabbits of New Zealand were randomly divided into sham operation group of 6 rabbits and SAH group of 18 rabbits. Rabbits model of SAH were made by endovascular puncturing,according to the observation time points they were divided into SAH third days group (group D3), fifth days group (group D5) and seventh days group (group D7), each group of 6 rabbits.The water content, malondialdehyde (MDA) content, and activity of total superoxide dismutase (T-SOD) of the brain tissues were measured in all groups.Result:Compared with the sham operated group,the SAH group’s water content and MDA content increased significantly,T-SOD activity decreased significantly(P<0.05).Furthermore,all the changes were most significantly in fifth days group after SAH (P<0.01).Conclusion:There is an enhancement of lipid peroxidation and lower oxygen free radical scavenging ability after SAH.Free radical injury maybe the main pathomechanism of brain edema after SAH.关键词
兔/蛛网膜下腔出血/丙二醛/超氧化物歧化酶/脑水肿Key words
Rabbits/Subarachnoid hemorrhage/Malondialdehyde/Superoxide dismutase/Brain edema引用本文复制引用
董广宇,禹婷婷,吴春波,王新军,廖一凡..蛛网膜腔出血后脑组织氧自由基代谢的实验研究[J].中国医学创新,2016,13(34):19-22,4.基金项目
深圳市龙岗区科技发展资金项目 （）
