吉林医药学院学报2017，Vol.38Issue(1)：1-6,6.
聚合物种类与介质类型对超饱和布洛芬与结晶性布洛芬在液态环境中的浓度影响
The effect of polymers and media types on the concentration of supersatura-ted and crystalline ibuprofen in liquid condition
摘要
Abstract
Objective To investigate the effect of polymers and media types on the concentration of supersaturated and crystalline ibuprofen in liquid condition .Methods Based on the methods of simulating liquid supersaturable process and adding crystalline ibuprofen ,the effect of nine types of polymers and five kind of media on the concentra-tion-time curve of BCSⅡdrug ibuprofen were analyzed through measuring the content of drugs at different time points using dissolution apparatus .Results The results showed that F127,β-CD and HP-β-CD possess the higher concen-tration, presenting more significant comprehensive ability of dissolution enhancement and crystallization inhibition effects.Conclusion Based on concentration-time curves,F127,β-CD and HP-β-CD are more suitable polymer car-riers in supersaturable drug delivery systems ( SDDS) ,which can effectively enhance the dissolution of crystalline drug and inhibit the crystallization of drugs .关键词
聚合物种类/介质类型/布洛芬/浓度-时间曲线/超饱和Key words
polymer types/media types/ibuprofen/concentration-time curve/superstaturable分类
医药卫生引用本文复制引用
时念秋,冯波,张勇,张秀荣,李正强,齐宪荣..聚合物种类与介质类型对超饱和布洛芬与结晶性布洛芬在液态环境中的浓度影响[J].吉林医药学院学报,2017,38(1):1-6,6.基金项目
吉林省科技发展计划资助项目（20160520046JH）；吉林省教育厅资助项目（吉教科合字2015第401号）；吉林市科技计划发展项目（201464053）；中国博士后科学基金面上项目（2015M571374）；吉林省科技发展计划项目（20140311110YY）． （）
