吉林医药学院学报2017，Vol.38Issue(1)：32-35,4.
不同工艺制得非洛地平固体分散体的溶解度比较研究
A comparative study on the solubility of felodipine solid dispersions based on different preparation methods
摘要
Abstract
Objective To optimized the preparation technology for felodipine solid dispersions by determining its sol-ubility.Methods Solid dispersions were prepared based on polymer carrier of copovidone ( PVP VA64) using four preparation methods ( coprecipitation method , microwave-quenching cooling method , freeze drying method and spray drying method ) .Equilibrium solubility was measured in the water and PBS ( pH 6 .8 ) .Results Pure drug and physical mixtures caused the relatively low solubility (<0.4 mg/L).Microwave-quench cooling technology resulted in the highest solubility (>1.4 mg/L),which was superior to other three methods .Conclusion Microwave-quench cooling technology improved the solubility of felodipine obviously ,and is more suitable for preparing felodipine solid dispersions in industrialized application .关键词
固体分散体/非洛地平/BCSⅡ类药物/制备工艺/溶解度Key words
solid dispersions/felodipine/BCS class Ⅱdrugs/preparation technology/solubility分类
医药卫生引用本文复制引用
张鸿,吕行,宋艳玲,张晓光,刘超,董钰婷,时念秋..不同工艺制得非洛地平固体分散体的溶解度比较研究[J].吉林医药学院学报,2017,38(1):32-35,4.基金项目
吉林医药学院2015年度吉林省大学生创新创业训练计划资助项目；吉林医药学院2014年度吉林省大学生创新创业训练计划资助项目；吉林省教育厅资助项目（2015401）；吉林市科技发展计划项目（201464053）；中国博士后科学基金面上项目（2015M571374）． （）
