高等学校化学学报2016，Vol.37Issue(12)：2138-2143,6.DOI:10.7503/cjcu20160563
N-（2-吡啶甲基）-L-丝氨酸铜配合物的合成、晶体结构及抑制蛋白酪氨酸磷酸酶活性
Synthesis,Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(Ⅱ) Complex with N-(2-Pyridylmethyl)-L-serine
摘要
Abstract
The reaction of the reduced Schiff base HL [N⁃(2⁃pyridylmethyl)⁃L⁃serine] with CuCl2·2H2O in molar ratio of 1∶1 in methanol solution afforded a new neutral mononuclear complex [CuLCl(H2O)](Ⅰ). The structure was determined by single⁃crystal X⁃ray diffraction and further characterized by elemental analysis, FTIR, electrospray ionization mass spectrometry and powder X⁃ray diffraction. In complex Ⅰ, the Cu(Ⅱ) ion adopts five⁃coordinated mode in a square pyramidal configuration which is completed by one oxygen and two nitrogen atoms from the L- anion, one chloride anion and one water molecule. The discrete copper coordination units were extended into a 2D supramolecular network through the intermolecular interac⁃tions. The bioactivity of the compound as a potential PTPs( Protein Tyrosine Phosphatases) inhibitory agent in vitro was investigated, displaying potent inhibition against PTP1B( IC50=0�32 μmol/L) and TCPTP ( IC50=0�45 μmol/L) .关键词
铜(Ⅱ)配合物/N-(2-吡啶甲基)-L-丝氨酸/抑制剂/蛋白酪氨酸磷酸酶1B(PTP1B)/T细胞蛋白酪氨酸磷酸酶(TCPTP)Key words
Copper(Ⅱ) complex/N-(2-Pyridylmethyl)-L-serine/Inhibitor/PTP1B/TCPTP分类
化学化工引用本文复制引用
李艳红,袁彩霞,卢丽萍,朱苗力,付学奇,邢述,高增强..N-（2-吡啶甲基）-L-丝氨酸铜配合物的合成、晶体结构及抑制蛋白酪氨酸磷酸酶活性[J].高等学校化学学报,2016,37(12):2138-2143,6.基金项目
国家自然科学基金（批准号21471092，21571118，21271121）资助．? Supported by the National Natural Science Foundation of China（ Nos．21471092，21571118，21271121）． （）
