口腔疾病防治2016，Vol.24Issue(12)：695-700,6.DOI:10.12016/j.issn.2096-1456.2016.12.003
氟化物Y500R珊瑚骨羟基磷灰石复合人工骨在兔颅面成骨效应的实验研究
The osteoplastic effect of Y500R coral hydroxyapatite composite grafts with fluoride on the rabbit skull
摘要
Abstract
Objective To explore the effect and changes in osteogenesis efficacy of CHA (Coral hydroxyapatite) com⁃posite grafts with fluoride in guided bone augmentation on rabbit skull. Methods Twenty⁃four rabbits were studied. Y500R CHA composite grafts contained fluoride and titanium cylinders were prepared. Two titanium cylinders on the test group's rabbit skull were filled with composite grafts contain fluoride and non⁃fluoride grafts were filled in the control group. Cyclomycin and calcein were injected, After 2, 4 and 6 weeks, the animals were sacrificed to obtain ground sec⁃tions for histology and histomorphometry. The general observation and area of highly fluorescent band of new bone forma⁃tion was measured after sample treatment. Results Significantly more neogenesis bone was augmented in the test groups than the control group. The osteoplastic effect in the test group more athletic. The experimental data had statistical signifi⁃cance (F=6.36, P=0.019 3). Conclusion Low concentration (1.0 × 10⁃7 mol/L~5.0 × 10⁃5 mol/L) fluoride can pro⁃mote bone formation effectively.关键词
氟/珊瑚骨羟基磷灰石/骨代用品/成骨效应/钛帽屏障Key words
Fluoride/Coral hydroxyapatite/Bone substitute/Osteogenesis effect/Itanium cylinder��s barrier分类
医药卫生引用本文复制引用
郭毅,周磊,谢建雅..氟化物Y500R珊瑚骨羟基磷灰石复合人工骨在兔颅面成骨效应的实验研究[J].口腔疾病防治,2016,24(12):695-700,6.基金项目
国家自然科学基金（81170998）；广东省医学科研基金 （）
