口腔疾病防治2016，Vol.24Issue(12)：701-705,5.DOI:10.12016/j.issn.2096-1456.2016.12.004
黄芩苷对氧化应激诱导牙龈上皮细胞凋亡的保护作用研究
Protective effect of baicalin on oxidative stress-induced apoptosis of gingival epithelial cells
摘要
Abstract
Objective To study the protective effect of baicalin on oxidative stress⁃induced gingival epithelial cell apoptosisand its mechanism. Methods H2O2 was employed to form the oxidative stress⁃induced gingival epithelial cells apoptotic model, with the intervention of baicalin. The cell proliferation rate, cell apoptosis level, the protein ex⁃pression of protein kinase B (Akt) and glycogen synthase kinase3β (GSK3β) were investigated respectively. Results Baicalin could effectively alleviate oxidative stress⁃induced inhibition of gingival epithelial cell proliferation and allevi⁃ate apoptosis;and it could promote the phosphorylation of Akt⁃GSK3βsignaling pathway. Conclusion Baicalin has a significant protective effect on oxidative stress⁃induced apoptosis of gingival epithelial cells, which may be related to the regulation of Akt⁃GSK3βsignal pathway.关键词
黄芩苷/氧化应激/凋亡/牙龈上皮细胞/牙周炎Key words
Baicalin/Oxidative stress/Apoptosis/Gingival epithelial cells/Periodontitis分类
医药卫生引用本文复制引用
赵树蕃,崔颖秋..黄芩苷对氧化应激诱导牙龈上皮细胞凋亡的保护作用研究[J].口腔疾病防治,2016,24(12):701-705,5.基金项目
广东省医学科研基金 （）
