中国妇幼健康研究2016，Vol.27Issue(11)：1393-1395,1396,4.DOI:10.3969/j.issn.1673-5293.2016.11.033
新辅助化疗局部晚期宫颈癌前后 Ki-67、P-gp表达水平及临床意义
Difference of Ki-67 and P-gp expression level before and after neoadjuvant chemotherapy for locally advanced cervical cancer and its clinical significance
应瑜 1王银雪 1王爱娇2
作者信息
- 1. 永康市妇幼保健院妇科
- 2. 病理科，浙江永康321300
- 折叠
摘要
Abstract
Objective To explore the changes of Ki-67 nuclear antigens (Ki-67) and P-glycoprotein (P-gp) before and after cervical cancer neoadjuvant chemotherapy and analyze their correlation with efficacy and sensitivity of chemotherapy , so as to provide theoretical basis for determination of sensitivity indicators of new adjuvant chemotherapy .Methods Fifty cases of cervical cancer in Ⅰb2~Ⅱb stage treated with neoadjuvant chemotherapy in Maternal and Child Health Care Hospital of Yongkang City were randomly selected .Expression levels of Ki-67 and P-gp in cervical tissue were determined by immunohistochemical method before and after chemotherapy .Correlation of the changes of expression with chemotherapy efficacy and sensitivity was calculated and analyzed .Results Overall effective rate of cervical cancer neoadjuvant chemotherapy was 86%, and 7 cases were stable .No patients showed progression .Positive expression rate of Ki-67 before chemotherapy was 90.00%, which was higher than that after chemotherapy (65.00%) with statistical significance (χ2 =23.67, P<0.05).Positive expression rate of P-gp before chemotherapy was 56.00%, which was 85.00% after chemotherapy.Difference had statistical significance (χ2 =21.98, P <0.05 ).Chemotherapy effective rate of Ki-67 positive patients was 91.11%, which was significantly higher than that of Ki-67 negative patients (χ2 =9.67, P<0.05).Chemotherapy effective rate of P-gp positive patients was 39.29%, and that of P-gp negative patients was 100.00%.The difference was statistically significant (χ2 =10.85, P <0.05). Inflammatory expression of Ki-67 and P-gp presented negative correlation (r=0.5872, P<0.05).Conclusion Positive expression rate of Ki-67 decreases after neoadjuvant chemotherapy for cervical cancer , while positive expression rate of P-gp increases , which can provide basis for clinical treatment .关键词
局部晚期宫颈癌/宫颈癌新辅助化疗/Ki-67/P-gp/相关性Key words
locally advanced cervical cancer/neoadjuvant chemotherapy for cervical cancer/Ki-67/P-gp/correlation分类
医药卫生引用本文复制引用
应瑜,王银雪,王爱娇..新辅助化疗局部晚期宫颈癌前后 Ki-67、P-gp表达水平及临床意义[J].中国妇幼健康研究,2016,27(11):1393-1395,1396,4.
