华西口腔医学杂志2016，Vol.34Issue(6)：639-642,4.DOI:10.7518/hxkq.2016.06.017
缺氧诱导因子-1α信号通路在髁突软骨生长和改建中的作用机制
Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling
摘要
Abstract
The condylar cartilage was adapted to hypoxic conditionsin vivo. However, condylar cartilage cells exposed in normoxiain vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated inin vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This review summarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilage repair.关键词
缺氧诱导因子-1α/髁突软骨/低氧/静压力Key words
hypoxia-inducible factor-1α/condylar cartilage/hypoxic/static pressure分类
生物科学引用本文复制引用
徐高丽,吴立立,吴枝武,谷志远..缺氧诱导因子-1α信号通路在髁突软骨生长和改建中的作用机制[J].华西口腔医学杂志,2016,34(6):639-642,4.基金项目
国家自然科学基金(81170979) （81170979）
浙江省医药卫生科技计划项目(2015KYB146).The National Natural Science Foundation of China (81170979) （2015KYB146）
Zhejiang Medical Science and Technology Plan Projects (2015KYB146). （2015KYB146）
