临床神经外科杂志2016，Vol.13Issue(6)：408-411,4.DOI:10.3969/j.issn.1672-7770.2016.06.003
微电极记录与影像技术联合应用对帕金森病脑深部电刺激最佳刺激治疗位置的研究
Optimal target localization for subthalamic stimulation in patients with Parkinson disease by MRI confirmation and microelectrode recordings
郭松 1庄平 1李建宇 1张宇清 1李勇杰1
作者信息
- 1. 100053 北京,首都医科大学宣武医院北京市功能神经外科研究所
- 折叠
摘要
Abstract
Objective To further determine the efficient contact area from deep brain stimulation ( DBS ) of the subthalamic nucleus ( STN ) in patients with Parkinson disease ( PD ) . Methods 40 patients with PD underwent the implantation of electrodes into the STN . Microelectrode recordings were performed in the STN during surgery and neuronal activity was analyzed offline .The distance between the target and the electrode was calculated individually in each axis MRI .Results Most of the space defined by the active contacts distribution was inside that defined by the STN-dorsal border distribution . Conclusion This approach proposed for the localization of the electrodes on MRI shows that DBS is most effective in the dorsal part of the STN .关键词
帕金森病/丘脑底核/微电极记录/脑深部电刺激/刺激位点Key words
Parkinson 's disease/subthalamic nucleus/microelectrode/deep brain stimulation/active contacts分类
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郭松,庄平,李建宇,张宇清,李勇杰..微电极记录与影像技术联合应用对帕金森病脑深部电刺激最佳刺激治疗位置的研究[J].临床神经外科杂志,2016,13(6):408-411,4.
