临床神经外科杂志2016，Vol.13Issue(6)：412-414,3.DOI:10.3969/j.issn.1672-7770.2016.06.004
立体定向丘脑腹中间核毁损术治疗书写痉挛的疗效评估
Stereotactic selective thalamotomy for treatment of writer's cramp
摘要
Abstract
Objective To explore the efficacy and safety of stereotactic selective thalamotomy for the treatment of writer's cramp( WC) .Methods 47 patients(32 men,15 women,age 15-64 years, mean 28.9 years) with medically intractable task-specific focal dystonia of the hand underwent Vim thalamotomy.The stereotactic target was chosen at ventralis intermedius nucleus. The mean duration of the symptom ranged from 2 to 21 years ( mean 5 .5 years ) .Results All patients showed immediate postoperative disappearance of dystonic symptoms , and the effect was sustained during the follow-up period ( 6-36 months, mean 23 months ) , except in 3 cases.One patient showed partial recurrence of the symptom and underwent second thalamotomy 6 months after the initial surgery with satisfactory results.The score on WC rating scale decreased significantly (P<0.001) after Vim thalamotomy.There were no permanent operative complications.There was no mortality or permanent morbidity.Conclusion Although a longer follow-up is needed, stereotactic Vim thalamotomy is a useful and safe therapeutic option for writer's cramp.关键词
书写痉挛/丘脑腹中间核/脑深部核团毁损术Key words
writer's cramp/ventralis intermedius nucleus of thalamotomy分类
医药卫生引用本文复制引用
李建宇,张宇清,庄平,李勇杰..立体定向丘脑腹中间核毁损术治疗书写痉挛的疗效评估[J].临床神经外科杂志,2016,13(6):412-414,3.基金项目
国家自然科学基金(81371256) （81371256）
