临床输血与检验2016，Vol.18Issue(6)：521-523,527,4.DOI:10.3969/j.issn.1671-2587.2016.06.003
1例部分D表型孕妇抗-D及基因型分析
A Case of Pregnant Woman with Partial Anti-D and Its Genotyping
摘要
Abstract
Objective To analyze anti-D and genotype of the partial D phenotype in a pregnant women.Methods The RhDCcEe antigens were detected in saline by microcolumn gel card method. The serum anti-D and its titers were detected by routine serological method. The partial D phenotype was confirmed by detecting10 RHD exons,zygosity and Depitops.Results The pregnant women was found to have dCcee in saline,but DCcee in gel card. RHD gene was found to have deletion of exons3-6 and the zygosity was D/d. Some of the red cell membrane D epitopes were negative. The results revealed a partial DVI-III phenotype with DVICe/dce genotype. The titer of anti-D was1:32 in week20 of pregnancy and1:64 just before delivery.Conclusion Several pregnancies with partial DVI-III phenotype have been reported who presented positive anti-D reaction and hemolytic disease of the newborns. DVI-III is not rare in Chinese and misdiagnosisshould be avoidedI in prenatal examination.关键词
Rh血型/D抗原/部分D型/抗-DKey words
Rh blood group/D antigen/Partial D/Anti-D Antibody分类
医药卫生引用本文复制引用
党鑫堂,吴筱莹,王学东,伍昌林,朱奕,李妙珊,邵超鹏..1例部分D表型孕妇抗-D及基因型分析[J].临床输血与检验,2016,18(6):521-523,527,4.基金项目
本课题受广东省医学研究基金（No.A2015054）、深圳市科技创新项目（No.JCYJ20140414170821221）资助 （）
