山东医药2016，Vol.56Issue(45)：1-5,5.DOI:10.3969/j.issn.1002-266X.2016.45.001
外周血细胞计数在 PGI-DLBCL 患者预后评估中的价值
Value of peripheral blood cell count in prognosis evaIuation of patients with PGI-DLBCL
摘要
Abstract
Objective To investigate the value of peripheral blood cell count in the prognosis evaluation of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL).Methods We retrospectively analyzed the clinical data from patients with newly diagnosed diffuse large B-cell lymphoma who were confirmed by pathology from March 2009 to May 2015.We analyzed the effects of the absolute lymphocyte count (ALC),absolute monocyte count (AMC), absolute lymphocyte count/absolute monocyte count ratio (LMR)and platelet count/absolute lymphocyte count ratio (PLR)on the 5-year overall survival (OS)and progression-free survival (PFS).One hundred and sixty-eight patients were divided into low risk,intermediate risk,intermediate to high risk and high risk groups according to international prog-nostic index (IPI)and aaIPI scores.According to the LMR combined with IPI or aaIPI we divided into three groups:(1) good prognosis group:LMR ≥2.5 and low risk patients,(2)poor prognosis group:LMR <2.5 and high risk patients, (3)general prognosis group:the rest of cases except the above.The OS and PFS was compared between these groups.Re-sults The mean age of all patients was 55 (12-90)years old,and the median follow-up was 25 (8-79)months.Univari-ate analysis showed that ALC,AMC,LMR and PLR were associated with the 5-year OS and PFS (all P <0.05).Multiva-riate analysis showed that 5-year PFS was related with ALC,LMR and LDH,and 5-year OS was related with age and LMR (all P <0.05).There were no significant difference in 5-year OS and 5-year PFS between intermediate to high risk group and high risk group (5-year OS was 32%,23.8%,and 5-year PFS was 20.0%,23.8%).There were statistically signif-icant differences in 5-year OS and 5-year PFS among good prognosis group,general prognosis group and poor prognosis group (5-year OS was 82.8%,60.0% and 14.3%;5-year PFS was 79.3%,53.8% and 14.8%,respectively).Con-clusion At the first visit,the peripheral blood cell count is valuable prognostic factor for patients with PGI-DLBCL,and LMR combined with IPI score is helpful for assessing the risk stratification of PGI-DLBCL in the early period.关键词
原发胃肠道弥漫大B细胞淋巴瘤/绝对淋巴细胞计数/绝对单核细胞计数/血小板计数/预后Key words
primary gastrointestinal diffuse large B-cell lymphoma/absolute lymphocyte count/absolute monocyte count/platelet count/prognosis分类
医药卫生引用本文复制引用
赵盼,于泳,王亚非,赵智刚,张翼鷟,王晓芳..外周血细胞计数在 PGI-DLBCL 患者预后评估中的价值[J].山东医药,2016,56(45):1-5,5.基金项目
国家自然科学基金资助项目（81272562）。 （）
