上海针灸杂志2016，Vol.35Issue(12)：1405-1409,5.DOI:10.13460/j.issn.1005-0957.2016.12.1405
针刺八脉交会穴联合活血荣络颗粒对脑梗死痉挛性瘫痪患者GABA、Gly水平的干预研究
Study on the Influence of Needling the Eight Confluent Points plus Huo Xue Rong Luo Granules on GABA and Gly in ;Patients with Spastic Paralysis After Cerebral Infarction
摘要
Abstract
Objective To observe the influence of needling the Eight Confluent Points plus Huo Xue Rong Luo granules on the levels of gamma-aminobutyric acid (GABA) and glycine (Gly) in patients with spastic paralysis after cerebral infarction. Method Sixty patients with spastic paralysis after cerebral infarction were randomized into a treatment group and a control group, 3 0 cases each. The control group was intervened by basic treatment, while the treatment group was by Huo Xue Rong Luo granules plus acupuncture at the Eight Confluent Points in addition to the basic treatment, for 6 treatment courses in total. Before the treatment, and after half-a-month, 1-month, and 3-month treatments, the Chinese Stroke Scale (CSS) and activities of daily living (ADL) were evaluated, the levels of GABA and Gly were detected by using high performance liquid chromatography (HPLC), and the therapeutic efficacies were compared. Result After half-a-month treatment, the CSS score dropped significantly in both groups (P<0.01), and the between-group difference was statistically significant (P<0.01);the ADL score (Barthel Index score) increased markedly in both groups (P<0.01), and the between-group difference was statistically significant (P<0.01); the level of serum GABA increased significantly in both groups (P<0.05), and the between-group difference was statistically significant (P<0.05);the level of serum Gly rose up significantly in both groups (P<0.01), and the between-group difference was statistically significant (P<0.05). After 1-month treatment, the CSS score dropped significantly in both groups compared to that before treatment (P<0.01), and the inter-group difference was statistically significant (P<0.01);the ADL score increased significantly in both groups compared to that before treatment (P<0.01), and the inter-group difference was statistically significant (P<0.01);the levels of serum GABA and Gly increased markedly in both groups compared to that before treatment (P<0.01), and the inter-group differences were statistically significant (P<0.01). After 3-month treatment, the CSS score dropped significantly in both groups compared to that before treatment (P<0.01), and the inter-group difference was statistically significant (P<0.01);the ADL score increased significantly in both groups compared to that before treatment (P<0.01), and the inter-group difference was statistically significant (P<0.01); the levels of serum GABA and Gly increased markedly in both groups compared to that before treatment (P<0.05), approaching the normal levels, and the inter-group differences were statistically insignificant (P>0.05). Conclusion Needling the Eight Confluent Points plus Huo Xue Rong Luo granules is effective in treating spastic paralysis after cerebral infarction, which is plausibly associated with the up-regulation of inhibitory neurotransmitters (GABA and Gly).关键词
针刺/穴,八脉交会/针药并用/脑梗死/痉挛/γ-氨基丁酸/甘氨酸Key words
Acupuncture/Point, Eight Confluent Points/Acupuncture medication combined/Cerebral infarction/Spasm/Gamma-aminobutyric acid (GABA)/Glycine (Gly)分类
医药卫生引用本文复制引用
李中,周德生,江元璋,胡华,陈瑶,刘利娟..针刺八脉交会穴联合活血荣络颗粒对脑梗死痉挛性瘫痪患者GABA、Gly水平的干预研究[J].上海针灸杂志,2016,35(12):1405-1409,5.基金项目
湖南省教育厅重点项目(14A111) （14A111）
长沙市科技计划项目(K1308023-31) （K1308023-31）
