摘要
Abstract
Objective To explore rhythmic variation about the relationship of adrenocorticotropic hormone (ACTH)and cor-tisol(Cor)with the essential hypertension at different time.Methods Chose 90 cases of patients in hospital and outpatient who visited the Second People’s Hospital of Jiaozuo between July 2012 and March 2014 with essential hypertension(EH) and furthere by coranory angiograph and head MRI or CT,they was divided into three groups:B groups (n=42),C groups (n=17)and D group (n=31).60 cases of healthy physical examination was as a control group.Detected plasma ACTH and serum Cor at 8∶00,16∶00,24∶00 o’clock with the radioimmunoassay.Results The plasma ACTH at 8∶00,16∶00,24∶00 o’clock of D group (18.23±6.36,11.29±7.35,5.69±3.02 pg/ml)were lower than A group (24.83±8.98,15.56± 8.56,9.45±2.22 pg/ml)with significant diffences (t=4.56,P=0.012).and other groups B,C,A showed no significant change (t=1.566,P>0.05).Serum cortisol levels,D group (326.53±56.3,176.9±59.6,165.2±42.5 ng/ml)and B groups (310.03±45.01,167.6±55.0,161.9±49.6 ng/ml)were higher than C groups (227.6±65.2,127.9±29.7,121.6 ±15.4 ng/ml)with significant difference (t=3.26,4.62,P=0.016).Three groups compared with the B group (127.6± 21.3,87.9±18.5,27.9± 6.5 ng/ml)had very significant difference (t=6.39,6.89 and 7.23,P=0.001).Conclusion ACTH levels were lower with cerebral ischemic stroke.There were elevated Cor in serum of pure essentian hypertension pa-tients,with amalgamative coronary heart disease (CHD)or ischemic stroke,serum cortisol levels were higher.关键词
促肾上腺皮质激素/皮质醇/单纯原发性高血压/原发性高血压伴冠心病/原发性高血压并发缺血性脑卒中Key words
adrenocorticotropic hormone/cortisol/simple essential hypertension/primary hypertension with coranary heart disease/primary hypertension complicated with ischemic stroke分类
医药卫生
