摘要
Abstract
Objective To cause hemolytic disease of the newborn to the outside by ABO irregular antibody (HDN)of the ex-change transfusion therapy,and explore its clinical significance.Methods Collected 2 3 1 1 cases of neonatal hemolytic disease in Xi’an High Tech Hospital from 2010 to 2015.The irregular antibody was screened by antiglobulin method of micro col-umn gel card and identifed by Liss-IAT tube method.Then analysed the types of irregular antibodies and related clinical data and curative effect after treatmentfor.Results In 2 3 1 1 cases of neonatal hemolytic disease samples,3 6 cases of irregular an-tibodies were detected 1.5 6% of the detection rate.In Rh system,Lewis system,Kidd system,Diego system were detected in 28 cases,3 cases,4 cases and 1 cases,the positive rates were 77.78%,8.33%,11.11%,2.78%;Rh blood group system in irregular antibody in 28 cases,anti-D,anti-E,anti-cE,anti-C,anti-Ce were detected in 2 cases,8 cases,11 cases,2 cases,5 ca-ses,the percentage of each antibody accounted for respectively 7.14%,28.57%,39.29%,7.14% and 17.86%.Before and after exchange transfusion hemoglobin t,with free bilirubin test before and after the transfusion hemoglobin was significantly higher in free bilirubin decreased significantly,the difference was statistically significant,of which 26 cases of exchange transfusion treatment.Conclusion Irregular antibody may cause serious hemolytic disease of the newborn,should be used in the detection of sensitive methods in clinical practice have an important role in exchange transfusion.关键词
不规则抗体/新生儿溶血病/换血治疗Key words
irregular antibody/hemolytic disease of newborn/blood transfusion therapy分类
医药卫生
