现代妇产科进展2016，Vol.25Issue(12)：900-903,4.DOI:10.13283/j.cnki.xdfckjz.2016.12.005
组织中长链非编码 RNA高表达是卵巢癌预后不良的危险因素：Meta分析
High expression of long non-coding RNA in tissues is associated with prognostic value in ovarian cancer patients:a Meta-analysis
潘青 1郭丹凤 1同芙菊 1李悦 1王晓慧1
作者信息
- 1. 兰州大学第一临床医学院，兰州 730000
- 折叠
摘要
Abstract
Objective:To systematically assess whether the LncRNA expression was as-sociated with overall survival and clinical feature for ovarian cancer patients. Methods:The da-tabases including PubMed,EMBASE database,the Cochrane Library,CNKI,CBM,and Wanfang database were searched from inception to July 22,2016 to identify the eligible studies. Literature selection,data extraction,and quality assessment were performed by two independent reviewers. STATA 12. 0 software was used for meta-analysis. Results:A total of 13 studies were included. The results of meta-analysis showed that the FIGO stage was associated with LncRNA expression ( P=0 . 000 ) . There were no statistical significant differences between other clinical features and LncRNA. Compared with LncRNA low expression,LncRNA high expression was associated with poor OS (HR=1. 97,95%CI为1. 69~2. 31,P=0. 000). Conclusions:LncRNA high expres-sion was associated with poor OS,which could be a predictor of short-term survival.关键词
长链非编码RNA/卵巢癌/Meta分析Key words
Long non-coding RNA/Ovary cancer/Meta-analysis分类
医药卫生引用本文复制引用
潘青,郭丹凤,同芙菊,李悦,王晓慧..组织中长链非编码 RNA高表达是卵巢癌预后不良的危险因素：Meta分析[J].现代妇产科进展,2016,25(12):900-903,4.
