摘要
Abstract
Objective:To discuss the influence of oxidative stress ( OS) to eutopic en-dometrial receptivity of patients with endometriosis( EMs) . Methods:Xanthine oxidase method and thiobarbituric acid colorimetric method were used to detect and contrast the levels of super-oxide dismutase ( SOD) and malondialdehyde ( MDA) in 60 cases of eutopic endometrium from patients with EMs ( EMs group ) , in which 24 cases of proliferative phase endometrium and 36cases of secretory phase endometrium,and 50 cases of normal endometrium(control group), in which 21 cases of proliferative phase endometrium and 29 cases of secretory phase endometri-um. The same method were used to detect and contrast the levels of SOD and MDA in 17 cases of endometrium during implantation window in control group( group A) ,12 cases of endometri-um during implantation window, the first month after resuming normal menstruation, coming from the patients after treatment and accepting Vc antioxidation treatment in EMs group( group B) ,11 cases of endometrium during implantation window,the first month after resuming normal menstruation,coming from the patients after treatment in EMs group( group C) and 23 cases ofendometrium during implantation window in EMs group ( groupD );Immunohistochemical stai-ning was used to detect and contrast the expression of integrin αvβ3 in endometrium of group A、B、C and D;Aanalyze the correlation of integrinαvβ3 and SOD、MDA levels in endometrium of group A、B、C and D. Results:Whether proliferative phase endometrium and secretory phase endometrium,the levels of SOD in EMs group were lower than that in control group(P<0. 05), while MDA was higher(P<0. 05). The endometrium during implantation window in 4 groups, the expression levels of SOD:group A>group B>group C>group D, the expression levels of MDA:group A< group B< group C< group D,the expression levels of integrin αvβ3:group A>group B>group C>group D;In group B、C and D,the expression of integrinαvβ3 and SOD was posititvely correlated(P<0. 05),the expression of integrinαvβ3 and MDA was negatively corre-lated(P<0. 05). Conclusion:OS presents in eutopic endometrium of patients with EMs,resul-ting in the decline of eutopic endometrium receptivity. After treatment,the OS in eutopic endo-metrium can be significantly relieved, and then improve the eutopic endometrium receptivity. Antioxidative treatment can play a supporting role.关键词
SOD/MDA/整合素αvβ3/在位内膜容受性Key words
SOD/MDA/integrin αvβ3/Receptivity of eutopic endometrium分类
医药卫生
