医学信息2016，Vol.29Issue(34)：52-53,2.
母婴分离对新生期大鼠成年后海马组织激肽释放酶8的影响
Effects of Maternal and Neonatal Isolation on KLK8 of Hippocampus in Neonatal Rats
张璐 1董文斌2
作者信息
- 1. 泸州市妇幼保健院新生儿科，四川 泸州 646000
- 2. 西南医科大学附属医院新生儿科，四川 泸州 64600
- 折叠
摘要
Abstract
Objective To detect the expression level of KLK8 in rats' hippocampal tissue after maternal separation, and explore the potential mechanism of rats' abnormal behavior resulted from maternal separation in neonatal period. Methods 24 Wistar neonatal rats were divided into maternal separation group and control group. Nothing was done to the rats in the control group. After 6 weeks, rats were killed.After the hippocampus tissue were determined by use of HE staining , The expression of KLK8 in rat's hippocampal tissue were detected by immunohistochemistry. Image-Pro Plus software which were used to semiquantitative assessment the immuneohistochemical images. Results Immunohistochemistry showed that KLK8 expression level in hippocampal tissue were significantly decreased in NMS group compared with the control group ( <0.01). Conclusion The expression of KLK8 were decreased in hippocampatissue after maternal separation, may to a certain extent affected the neural signal transduction and synaptic plasticity,which are possibly related to the rats' abnormal behavior.关键词
母婴分离/海马/激肽释放酶8Key words
Maternal separation/Hippocampus/Tissue kallikrein 8/Abnormal behavior引用本文复制引用
张璐,董文斌..母婴分离对新生期大鼠成年后海马组织激肽释放酶8的影响[J].医学信息,2016,29(34):52-53,2.
