摘要
Abstract
Objective To study the clinical and imaging characteristics of Fahr disease in China .Methods By u-sing the Meta-analysis of evidence-based medicine,the records of Fahr disease patients in The First Affiliated Hospital of Chongqing Medical University from January .2012 to January .2016 and the literatures of Fahr disease in China from 1998 to 2015 were collected.The demographic data ,clinical manifestations and imaging findings of patients with Fahr disease were analyzed.Results Of the total 395 cases,106 had integral data,including 6 from The First Affiliated Hospital of Chongqing Medical University and 100 from literature.There were 213 males and 182 females,with a age of onsetting in 1. 5-85 years.The ratio of sporadic and familial cases respectively are were 79% and 16%.Aphasis(20% ),hypophrenia (15%),dementia (13%),dystaxia (11%),psychogeny (9%) are were the main performances of familial cases ,and diz-ziness (17%),epilepsy(15%),dystaxia (10%)are were the main symptoms of sporadic cases .The CT demonstrated that Fahr disease mainly presented the bilateral and symmetrical calcification in the basal ganglia areas ( 98%) , dentatum (30%),thalami(20%),etc.The levels of serumal calcium,phosphorus and parathormone were normal in the laboratorial examination.Conclusion Consistent with dizziness,epilepsy,mental retardation,movement disorders,ataxia are the main symptoms of Fahr disease ,but the symptoms in sporadic and familial of Fahr disease are different .The clinical diagnosis of Fahr disease is not difficult by combining the imaging characteristics and the levels of serum calcium ,phosphorus ,PTH,cal-citonin.关键词
Fahr病/对称性钙化/血清钙/磷水平/甲状旁腺激素/CTKey words
Fahr disease/Symmetrical calcification/Serum calcium/Phosphorus/PTH/CT分类
临床医学
