中国病理生理杂志2016，Vol.32Issue(12)：2291-2294,4.DOI:10.3969/j.issn.1000-4718.2016.12.029
丹参酮 IIA 对急性脑缺血大鼠心肌单相动作电位的影响
Effects of tanshinone IIA on cardiac monophasic action potential in acute cerebral ischemia rats
赵静 1陈晨1
作者信息
- 1. 复旦大学附属肿瘤医院心肺功能室，复旦大学上海医学院肿瘤学系，上海200032
- 折叠
摘要
Abstract
AIM:To investigate the effects of tanshinone IIA ( Tan) on cardiac action potential in rats with a-cute cerebral ischemia (ACI).METHODS:ACI was established in rats accordingly .Animals were divided into 3 groups:sham group, ACI group, and ACI with Tan treatment group .The defect of neural function in each group was graded , elec-trocardiogram was measured , monophasic action potential was recorded , and the levels of cardiac troponin I ( cTnI ) and creatine kinase-MB ( CK-MB) were examined by commercially available kits .RESULTS:Compared with ACI group , Tan significantly decreased the scores of the defect of neural function , reduced the incidence and duration of the abnormalities in electrocardiogram , prolonged the effective refractory period , action potential duration at 50%repolarization and action po-tential duration at 90%repolarization, and inhibited the elevation of cTnI and CK-MB levels.CONCLUSION:Tan main-tains a stable heart rhythm in ACI rats , which may be related to its protective effect on ischemic myocardium .关键词
丹参酮IIA/脑缺血/动作电位Key words
Tanshinone IIA/Cerebral ischemia/Action potential分类
医药卫生引用本文复制引用
赵静,陈晨..丹参酮 IIA 对急性脑缺血大鼠心肌单相动作电位的影响[J].中国病理生理杂志,2016,32(12):2291-2294,4.
