中国当代儿科杂志2016，Vol.18Issue(12)：1237-1241,5.DOI:10.7499/j.issn.1008-8830.2016.12.008
猪肺表面活性物质联合布地奈德混悬液气管内滴入治疗新生儿胎粪吸入综合征的疗效观察
Clinical efficacy of porcine pulmonary surfactant combined with budesonide suspension intratracheal instillation in the treatment of neonatal meconium aspiration syndrome
摘要
Abstract
Objective To study the clinical efficacy of porcine pulmonary surfactant (PS) combined with budesonide suspension intratracheal instillation in the treatment of neonatal meconium aspiration syndrome (MAS). Methods Seventy neonates with MAS were enrolled for a prospective study. The neonates were randomly assigned to PS alone treatment group and PS+budesonide treatment group (n=35 each). The PS alone treatment group was given PS (100 mg/kg) by intratracheal instillation. The treatment group was given budesonide suspension (0.25 mg/kg) combined with PS (100 mg/kg). Results The rate of repeated use of PS in the PS+budesonide group was signiifcantly lower than that in the PS alone group 12 hours after treatment (P<0.05). The improvement of PaO2/FiO2, TcSaO2, PaO2, and PaCO2 in the PS+budesonide group was signiifcantly greater than that in the PS alone group 6, 12, and 24 hours after treatment (P<0.05). The chest X-ray examination showed that the pulmonary inflammation absorption in the PS+ budesonide group was significantly better than that in the PS alone group 48 hours after treatment (P<0.05). The incidence of complications in the PS+budesonide group was signiifcantly lower than that in the PS alone group (P<0.05), and the average hospitalization duration was signiifcantly shorter than that in the PS alone group (P<0.01). Conclusions PS combined with budesonide suspension intratracheal instillation for the treatment of neonatal MAS is effective and superior to PS alone treatment.关键词
肺表面活性物质/布地奈德混悬液/胎粪吸入综合征/新生儿Key words
Pulmonary surfactant/Budesonide suspension/Meconium aspiration syndrome/Neonate引用本文复制引用
谭秀贞,吴时光,张建华,李晓芬,高平明,王宇..猪肺表面活性物质联合布地奈德混悬液气管内滴入治疗新生儿胎粪吸入综合征的疗效观察[J].中国当代儿科杂志,2016,18(12):1237-1241,5.基金项目
佛山市卫生和计生局医学科研课题（20160170）。 （）
