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PD-1和PD-L1在肺类癌中的表达情况和其临床意义OA北大核心CSCDCSTPCD

Expression and Clinical Signiifcance of PD-1 and PD-L1 in Pulmonary Carcinoids

中文摘要英文摘要

背景与目的肺类癌(pulmonary carcinoid, PC)是一种发病率极低的肺部原发性恶性肿瘤,临床预后与其病理特征密切相关。本研究旨在检测分析PC组织中PD-1(programmed death-1)和PD-L1(programmed death ligand-1)的表达情况及其与类癌患者临床病理生理特征的相关性。方法应用免疫组织化学法检测了20例PC石蜡包埋组织标本中PD-1和PD-L1的蛋白表达情况;应用Hscore(HS)评分系统…查看全部>>

Background and objective The incidence of pulmonary carcinoid (PC) is very rare in primary lung malignant tumors, and the prognosis of this disease is closely associated with its pathological features. In this study, the expres-sions of programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1) in lung carcinoid cells were detected, and the correlation between the expression and corresponding clinical physiological and pathologic features was further an…查看全部>>

李明彪;徐嵩;范海洋;张宏毅;李颖;李永文;刘明辉;刘红雨;陈军

300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室300052天津,天津医科大学总医院肺部肿瘤外科,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室

肺肿瘤肺类癌PD-1PD-L1

Lung neoplasmsPulmonary carcinoidProgrammed death-1 (PD-1)Programmed death ligand-1&nbsp

《中国肺癌杂志》 2016 (12)

PDGFR和Rb-E2F信号通路在EGFR-TKIs获得性耐药机制中的作用研究

847-853,7

本研究受国家自然科学基金(No.81172233、No.81372306和No.81301812)、天津自然科学基金重点项目(No.16JCZDJC34200)、天津自然科学基金项目(No.13JCYBJC22600)、教育部高等学校博士学科点专项科研基金(No.20131202110004和No.20131202120004)、天津市创新平台专项市级重点实验室建设项目(No.16PTSYJC00160)、中华人民共和国人力资源和社会保障部留学人员科技活动项目择优资助项目、天津市留学人员科技活动启动项目择优资助计划项目资助@@@@ This study was supported by the grants from the National Natural Science Foundation of China (to Jun CHEN)(No.81172233)(to Hongyu LIU)(No.81372306)(to Song Xu)(No.81301812), the Science and Technology Support Key Program of Tianjin (to Jun CHEN)(No.16JCZDJC34200), the Tianjin Natural Science Foundation (to Jun CHEN)(No.13JCYBJC22600), the Specialized Research Fund for the Doctoral Program of Higher Education (to Jun CHEN )(No.20131202110004)(to Song Xu)(No.20131202120004), the Municipal Key Laboratory Construction Project of Tianjin Innovative Platform Special (to Hongyu LIU)(No.16PTSYJC00160), the Scientiifc Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (to Song Xu), the Tianjin Scientiifc Research Foundation for the Re-turned Overseas Chinese Scholars (to Song Xu)

10.3779/j.issn.1009-3419.2016.12.07

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