中国免疫学杂志2016，Vol.32Issue(12)：1797-1800,4.DOI:10.3969/j.issn.1000-484X.2016.12.016
未治疗HIV感染者NKT样细胞活化、凋亡和增殖的相关研究
Studies on activation,apoptosis and proliferation of NKT like cells in untreated HIV infected patients
摘要
Abstract
Objective:To study the changes of the NKT like cells after HIV infected. Methods:We collected peripheral blood from 47 untreated HIV infected individuals and 31 healthy controls,and analyzed the expression of Annexin-V,Ki-67,HLA-DR and other surface molecules in NKT like cells by flow cytometry. Results:The NKT like cell percentage of untreated HIV infected group was (3. 03±1. 61)%,the NKT like cell percentage of normal control group was (8. 30±7. 42)%,the percentage of NKT like cells in HIV infected individuals was significantly lower than the healthy controls ( P<0. 05 );the NKT like cell HLA-DR expression of untreated HIV infected group and normal control group were (5. 40±4. 10)% and (0. 89±0. 83)%,the NKT like cell Annexin-V expression of untreated HIV infected group and normal control group were (30. 21±13. 15)% and (5. 40±8. 05)% ,and the activation and apoptosis of NKT like cells was significantly higher after HIV infection compared with health individuals (P<0. 001,P<0. 01),the degree of activation was negatively correlated with CD4 count (r=-0. 885 7,P<0. 05);and the NKT like cell Ki-67 expression of untreated HIV infected group and normal control group were (11. 15±4. 76)% and (27. 63±18. 31)%,the proliferation ability was significantly lower after HIV infection compared with healthy controls(P<0. 05). Conclusion:HIV infection can significantly reduce the number of NKT like cells and its ability to proliferate,and increase its ability to activation and apoptosis.关键词
HIV/AIDS/NKT样细胞Key words
Human immunodeficiency virus/Acquired immune deficiency syndrome/NKT like cells分类
医药卫生引用本文复制引用
刘婷婷,赵雪,张子宁,傅雅静,姜拥军..未治疗HIV感染者NKT样细胞活化、凋亡和增殖的相关研究[J].中国免疫学杂志,2016,32(12):1797-1800,4.基金项目
本文为国家科技重大专项课题资助项目(2014ZX10001002001004)和基础临床紧密结合平台项目(医大发字[2013]5号)。 （2014ZX10001002001004）
