中国药房2016，Vol.27Issue(35)：4998-4999,5000,3.DOI:10.6039/j.issn.1001-0408.2016.35.34
重组人白介素-11治疗化疗引起的血小板减少症的临床观察
Clinical Observation of Recombinant Human Interleukin-11 in the Treatment of Chemotherapy-induced Thrombocytopenia
黄辉 1章展 1李建华 1唐小万 1陈莉莉1
作者信息
- 1. 台州市第一人民医院血液肿瘤内科，浙江台州 318020
- 折叠
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of recombinant human interleukin-11 (rhIL-11) in the treat-ment of chemotherapy-induced thrombocytopenia. METHODS:86 patients with thrombocytopenia induced by chemotherapy were selected and divided into control group and observation group according to random number table,with 43 cases in each group. Con-trol group was given platelet transfusion 10 IU,once every 2-3 d;observation group was given Recombinant human IL-11 for injec-tion 25-50 μg/kg,qd. Both groups received treatment for 14 d. Clinical efficacies of 2 groups were observed as well as platelet count before and after treatment. The duration of platelet decrease and recovery,the occurrence of ADR were compared between 2 groups. RESULTS:The total effective rate of observation group was 81.40%,which was significantly higher than 62.79% of con-trol group,with statistical significance (P<0.05). There was no statistical significance in platelet count between 2 groups before treatment(P>0.05);after treatment,platelet count of 2 groups increased significantly,and the observation group was significant-ly higher than the control group,with statistical significance(P<0.05). The duration of platelet count <50×109 L-1,the time of platelet count recovering to 70×109 L-1 and 100×109 L-1 in observation group were significantly shorter than in control group,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CON-CLUSIONS:rhIL-11 shows good therapeutic efficacy in the treatment of chemotherapy-induced thrombocytopenia,and can signifi-cantly improve platelet count,shorten the duratione of platelet decrease and recovery with good safety.关键词
血小板减少症/重组人白介素-11/临床疗效/安全性Key words
Thrombocytopenia/Recombinant human interleukin-11/Clinical efficacy/Safety分类
医药卫生引用本文复制引用
黄辉,章展,李建华,唐小万,陈莉莉..重组人白介素-11治疗化疗引起的血小板减少症的临床观察[J].中国药房,2016,27(35):4998-4999,5000,3.
