中国医科大学学报2016，Vol.45Issue(12)：1082-1085,4.DOI:10.12007/j.issn.0258-4646.2016.12.006
同种异体牙源性骨移植材料修复兔颅骨缺损的实验研究
Experimental Study of the Repair of Rabbit Skull Defects with Allogeneic Tooth Derived Bone Graft Material
摘要
Abstract
Objective To evaluate the osteogenesis of rabbit allogeneic tooth derived bone graft material by histological detection ,so as to provide quality and cheap repair materials for the repair of bone defects in dental implants. Methods The bone graft materials were prepared using rab⁃bits allogeneic extracted teeth. A total of 28 adult Japanese healthy rabbits were selected to establish the cranial defect model with three 8 mm diam⁃eter holes. The allogenic tooth derived bone graft material were implanted into the experimental group. The artificial bone repair material was used as the control group,and the control group did not receive any implantion. Tetracycline labeling was performed after operation,the specimens were taken at 4,8 and 12 weeks after operation,and then the gross observation,X⁃ray examination,preparation of hard tissue sections,and HE staining were carried out. Results Histological analysis at 4,8 and 12 weeks after operation showed that there was an increasing trend the new bone for⁃mation in both experimental group and the control group ,and the experimental group was better;the trabecular bone structure of the blank group was scarce and the change was not obvious. Conclusion Allogenic tooth derived bone graft materials can promote the repair of bone defect ,and the effect is better than that of artificial bone repair materials.关键词
颅骨缺损/同种异体牙源性骨移植材料/人工骨修复材料/成骨作用Key words
skull defect/allogenic tooth derived bone graft materials/artificial bone repair materials/osteogenesis分类
医药卫生引用本文复制引用
王媛,王稚英,王明..同种异体牙源性骨移植材料修复兔颅骨缺损的实验研究[J].中国医科大学学报,2016,45(12):1082-1085,4.基金项目
辽宁省省直医院改革重点临床科室诊疗能力建设项目 （）
