中国医科大学学报2016，Vol.45Issue(12)：1105-1109,5.DOI:10.12007/j.issn.0258-4646.2016.12.011
晚期妊娠合并重度子痫前期患者血栓弹力图特点分析
Characteristics of Thromboelastography in Patients with Advanced Pregnancy Complicated with Severe Preeclampsia
摘要
Abstract
Objective To analysis the characteristics of thromboelastography and coagulation test in patients with advanced pregnancy combined with severe preeclampsia. Methods A retrospective single⁃center study was conducted. 35 patients with advanced pregnancy combined with se⁃vere preeclampsia who were admitted to hospital from January 2012 to December 2014 were analyzed compared to 43 third trimester patients with⁃out any complication. All the patients were treated based on the routine strategy. Blood sample were taken from the middle elbow vein to test blood cell count,serum biochemistry test,routine coagulation test and thromboelastography. All the results,including R,K,CI,α⁃angle and MA value, were compared between two groups. Analysis was performed to evaluate the correlation between all parameters of TEG and coagulation test. Re⁃sults There was no statistical significance between two groups in age ,prothrombin time and activated partial prothrombin time. In the severe pre⁃eclampsia group,the R value of TEG was increased(5.21±1.20 min vs 6.19±1.55 min,t=-3.144,P=0.002),α⁃angel was decreased(64.43°± 7.90° vs 60.37°±7.09°,t=2.367,P=0.02),and CI was decreased(0.81±2.27 vs-0.37±1.82,t=2.495,P=0.015). In blood cell count test,the platelets count was decreased in severe preeclampsia group[(217.48±65.68)×109/L vs(166.65±61.39)×109/L,t=3.500,P=0.001]. In routine coagulation test,only thrombin clotting time was increased in severe preeclampsia group(14.59±0.51 s vs 15.28±0.97 s,F=-3.800,P<0.001). In serum biochemistry test,the albumin was decreased in severe preeclampsia group(34.75±3.90 g/L vs 28.77±4.05 g/L,t=6.632,P<0.001),while serum urea nitrogen was increased(2.78±0.87 mmol/L vs 5.98±8.07 mmol/L,F=-2.333,P=0.026). In correlation analysis,thrombin clot⁃ting time had relationship between R(r=0.290,P=0.010),CI(r=-0.257,P=0.023)andα⁃angle(r=-0.243,P=0.032). Platelets count cor⁃related with CI(r=0.383,P=0.001),K(r=-0.409,P<0.001),α⁃angle(r=0.375,P=0.001)and MA(r=0.512,P<0.001). Conclusion For those who suffered from severe preeclampsia patients with advanced pregnancy,low coagulation function occurs in most of the patients com⁃pared to those patients without any complications. Thromboelastography may be helpful for those who have high risk factors ,especially with low platelets count and increased thrombin clotting time ,so as to reduce the incidence of bleeding or thromboembolic diseases.关键词
血栓弹力图/重度子痫前期/晚期妊娠/凝血功能Key words
thromboelastography/severe preeclampsia/late pregnancy/coagulation function分类
医药卫生引用本文复制引用
贾佳,杨巧妮,赵子房,秦含玉,王秋实,臧彬..晚期妊娠合并重度子痫前期患者血栓弹力图特点分析[J].中国医科大学学报,2016,45(12):1105-1109,5.基金项目
辽宁省自然科学基金（201102293）；辽宁省省直医院改革重点科室临床诊疗能力建设项目 （）
