中国药理学与毒理学杂志2016，Vol.30Issue(11)：1198-1205,8.DOI:10.3867/j.issn.1000-3002.2016.11.011
阿尔茨海默病与肠道菌群的关系及菌群调节对其防治的展望
Relationships between intestinal microbiota and Alzheimer disease and regulation of microbiota on prevention and treatment of Alzheimer disease:review
摘要
Abstract
With the extension of human life,the number of patients with Alzheimer disease(AD) is increaseing. However,the mechanisms of AD are still not very clear and there is no effective preven⁃tion and treatment process for this disease. In recent years,the importance of intestinal microbiota in the health field has been gradually elaborated,which has become a new research area for AD. There is chronic inflammation,a low level of neurotransmitter 5-hydroxy tryptamine and neurotrophic factor in the central nervous system of AD patients,and a changed structure of AD intestinal microbiota. The intestinal microbiota can cause chronic inflammation,produce neurotoxic substances,and may be related to obesity,type 2 diabetes and other metabolic diseases which are AD high-risk disease, suggesting the correlation between AD and intestinal microbiota. Intestinal microbiota can be regulated by probiotics , prebiotics and traditional Chinese materia medica and beneficial microbiota can reduce inflammation and the occurrence of metabolic syndrome such as diabetes,increase the level of brain neurotransmitter 5-hydroxytryptamine and neurotrophic factor and improve cognitive function. Intestinal microbiota regu⁃lation may become a new approach to the prevention and treatment of AD.关键词
阿尔茨海默病/肠道菌群/代谢物Key words
Alzheimer disease/intestinal microbiota/metabolites分类
生物科学引用本文复制引用
周珂新,徐雷艇,马银娟,周佳思,戴嘉佳,梁丽丽,魏华..阿尔茨海默病与肠道菌群的关系及菌群调节对其防治的展望[J].中国药理学与毒理学杂志,2016,30(11):1198-1205,8.基金项目
国家自然科学基金（31600402）；浙江省病理生理学技术研究重点实验室人才引进基金项目（ZJKLP201401）；浙江省自然科学基金项目（Y16H070001）；宁波大学科研基金项目（XKL14D2106）；宁波大学科研基金项目（XYL14021）；宁波大学科研基金项目（ZX2014000128）@@@@The project supported by National Natural Science Foundation of China（31600402）；Zhejiang Pro-vincial Key Laboratory of Pathophysiology Fund Project （ZJKLP201401）；Natural Science Fund Project of Zhejiang Province（Y16H070001）；Ningbo University Scientific Research Fund Project（XKL14D2106）；Ningbo University Scien-tific Research Fund Project（XYL14021）；and Ningbo University Scientific Research Fund Project （）
