中国医学创新2016，Vol.13Issue(31)：10-12,13,4.DOI:10.3969/j.issn.1674-4985.2016.31.003
联合检测血浆及支气管肺泡灌洗液（1-3）β-D-葡聚糖对侵袭性肺部真菌感染的临床诊治价值
Clinical Diagnosis and Treatment Value of Joint Detection of Plasma and Bronchoalveolar Lavage Fluid (1-3)β-D-glucan in Invasive Pulmonary Fungal Infection
摘要
Abstract
Objective:To discuss the clinical diagnosis and treatment value of joint detection of plasma and bronchoalveolar lavage fluid (BALF) (1-3) β-D-glucan in invasive pulmonary fungal infection.Method:100 patients with invasive pulmonary infection were selected from June 2014 to May 2016 in our hospital as infection group.According to the nature of pathogen,all patients were divided into fungal group of 42 cases and bacteria group of 58 cases,at the same time 30 cases with healthy physical examination center were chosen as health group. The latex enhanced immune turbidimetric method was used to detect (1-3) β-D-glucan level(G test),ROC curve analysis was used to analyze blood plasma and BALF G test value to the diagnosis of invasive pulmonary fungal infection,all the research objects of blood plasma and BALF G test were analysed.Result:Fungal group G test levels of plasma and BALF were obviously higher than that of healthy group and bacteria group,the differences were statistically significant(P<0.05).ROC curve analysis showed that,the BALF G test with 10 ng/L as the critical value of invasive pulmonary fungal infection,the diagnostic,sensitivity and accuracy of the specific degree were 76.83%,89.73% and 76.83% respectively;the plasma G test with 20 ng/L as the critical value,the diagnostic,sensitivity and accuracy of the specific degree were 78.47%,91.68% and 84.43% respectively;the two joint as the critical value,diagnostic,sensitivity and accuracy of the specific degree were 85.92%,96.41%and 93.28% respectively.In the diagnosis of sensitivity, accuracy and specific degree,BALF G experiment<plasma G<the two joint,the differences were statistically significant(P<0.05).Conclusion:Plasma and BALF G test levels changes associated with invasive pulmonary fungal infection,joint detection the level of invasive pulmonary fungal infection has better sensitivity,specificity and accuracy,it’s worth for further clinical promotion.关键词
血浆/支气管肺泡灌洗液/(1-3)β-D-葡聚糖/侵袭性肺部真菌感染/诊断Key words
Plasma/Bronchoalveolar lavage fluid/(1-3) β-D-glucan/Invasive pulmonary fungal infection/Diagnosis引用本文复制引用
黄耀光,李伟杰,苏伟强,林辉斌,陈虹,温琼娜..联合检测血浆及支气管肺泡灌洗液（1-3）β-D-葡聚糖对侵袭性肺部真菌感染的临床诊治价值[J].中国医学创新,2016,13(31):10-12,13,4.基金项目
湛江市科技计划项目 （）
