中国中医药信息杂志2017，Vol.24Issue(1)：37-40,4.DOI:10.3969/j.issn.1005-5304.2017.01.010
清热活血合剂治疗血热型寻常型银屑病临床研究
Clinicla Research onQingre Huoxue Mixture in Treating Blood Heat Type Psoriasis Vulgaris
摘要
Abstract
Objective To investigate the efficacy and safety ofQingre Huoxue Mixture in the treatment of blood heat type psoriasis vulgaris.Methods The patients were divided into treatment group and control group according to random number table method, with 52 cases in treatment group and 50 cases in the control group, 10 cases failed to complete the trial. Treatment group was givenQingre Huoxue Mixture, and the control group received oral administration of compoundQingdaiCapsule. The treatment lasted for 8 weeks. PASI score, TCM syndrome integrals, DLQI score, serum IFN-γ and IL-10 were detected, and hematuria routine and liver and kidney function were under safety testing before and after treatment.Results After treatment, PASI score, DLQI score and TCM syndrome integrals in the treatment group decreased significantly (P<0.001); the expression of serum IFN-γ decreased significantly (P<0.001); the expression of serum IL-10 increased significantly (P<0.001), with the total effective rate of 100% (52/52). After the treatment, TCM syndrome integrals in the both groups decreased significantly (P<0.001). After the treatment, the rash burning and itching scores in the treatment group were lower than the control group, with statistical significance (P<0.001). In terms of safety, the treatment group had no abnormal indicators.ConclusionQingre Huoxue Mixture has obvious curative effect, which can reduce the patients with psoriasis, improve the life quality of patients, and improve the clinical symptoms of rash burning and itching, reduce serum IFN-γ, and increase serum IL-10.关键词
清热活血合剂/血热证/寻常型银屑病Key words
Qingre huoxue Mixture/blood heat syndrome/psoriasis vulgaris分类
医药卫生引用本文复制引用
丁佩军,顾志英,徐平,李星子,贺旭峰,张慧敏..清热活血合剂治疗血热型寻常型银屑病临床研究[J].中国中医药信息杂志,2017,24(1):37-40,4.基金项目
上海市科委基金项目（13401902504）；上海市“杏林新星”人才项目 （）
