神经药理学报2016，Vol.6Issue(1)：58-64,7.DOI:10.3969/j.issn.2095-1396.2016.01.008
帕金森病相关基因DJ-1与氧化应激
Parkinson Associated DJ-1 Gene and Oxidative Stress
摘要
Abstract
Parkinson’s disease is characterized by the substantia nigra pars compacta dopaminergic neuron-specific death and the presence of eosinophilic inclusion bodies-Lewy bodies which’s main component isα- synuclein in residual neuronal. Recent studies show that oxidative stress is a leading cause of brain dopaminergic neuron-specific death. DJ-1(Park7)gene is an autosomal recessive Parkinson’s disease related genes. DJ-1 protein has a strong antioxidant effect,mainly acts as identity of active oxygen scavenger,chaperones,signaling pathways regulating molecules to against the oxidative stress,thereby protecting dopamine neurons from damage. Both deletion and mutation of DJ-1 gene will cause the reduction of its anti-oxidative stress,resulting in neuronal death,and this situation may be rescued by over-expression of DJ-1 protein. Because of the important role of DJ-1 in the development and occurrence of Parkinson’s disease,the paper will expand on its review of new research,and discuss primarily from the relationship between DJ-1 and oxidative stress.关键词
帕金森病/DJ-1/氧化应激/活性氧Key words
Parkinson’s disease(PD)/DJ-1/oxidative stress/reactive oxygen species (ROS)分类
医药卫生引用本文复制引用
娄钰霞,张钊,王真真,姜懿纳,张毅,李林,陈乃宏..帕金森病相关基因DJ-1与氧化应激[J].神经药理学报,2016,6(1):58-64,7.基金项目
国家自然科学基金项目（No.81274122、No.81373997、No.81273629、No.81473376、No.U1402221、No.81573640），北京市自然科学基金项目（No.7131013、No.7161011），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150），神经变性病教育部重点实验室开放研究课题（No.2016SJBX03），湖南省重点研发计划项目（No.2015SK2029-1），湖南省教育厅高校科研经费开放基金项目 （）
