河北医学2016，Vol.22Issue(12)：1937-1939,3.DOI:10.3969/j.issn.1006-6233.2016.12.001
氯吡格雷对非ST段抬高型急性冠脉综合征患者血小板聚集率的影响及近期临床疗效观察
Clopidogrel on the Platelet Aggregation Rate and its Short-term Clinical Efficacy in Patients with Non-ST-segment Elevation Acute Coronary Syndrome
摘要
Abstract
Objective: To investigate the effect of clopidogrel on the platelet aggregation rate and its short-term clinical efficacy in patients with non-ST-segment elevation acute coronary syndrome ( NSTE-ACS) . Methods:80 eligible patients were selected and randomly divided into observation group and control group, with 40 patients in each group. The patients of both groups were given conventional therapies;and the control group used aspirin additionally, while the observation group used clopidogrel additionally. The platelet aggregation rates and clinical efficacy were observed in the two groups. Results:After 30 days treatment, the observation group had significantly better efficacy than the control group ( P<0.05) . Before treatment, the two groups had insignificantly different platelet aggregation rates ( P>0.05);after 30 days treatment, both groups had significantly decreased platelet aggregation rates compared with those before treatment, but the observation group had a significantly better improving extent than the control group (P<0.05). In the treatment period, the observation group had a significantly lower incidence of main cardiovascular events than the control group (5.0% vs. 22.5%) (P<0.05). Conclusion:Clopidogrel in treatment of NSTE-ACS can effectively decrease the platelet aggregation rate, elevate clinical efficacy, decrease the incidence of cardiovascular events, and improve the short-term prognosis.关键词
非ST段抬高型急性冠脉综合征/氯吡格雷/血小板聚集率Key words
Non-ST-segment elevation acute coronary syndrome/Clopidogrel/Platelet aggrega-tion rate引用本文复制引用
徐岩鹰,周恕敏,吴军..氯吡格雷对非ST段抬高型急性冠脉综合征患者血小板聚集率的影响及近期临床疗效观察[J].河北医学,2016,22(12):1937-1939,3.基金项目
四川省科技厅科研项目,(编号:0130101) （编号:0130101）
