河北医学2016，Vol.22Issue(12)：1948-1951,4.DOI:10.3969/j.issn.1006-6233.2016.12.005
前列地尔联合丹红对早期糖尿病肾病患者肾功能及血清炎症因子水平的影响
Alprostadil Combined with Danhong on the Renal Function and Serum Levels of Inflammatory Factors in Patients with Early Diabetic Nephropathy
摘要
Abstract
Objective: To investigate the effects of alprostadil combined with Danhong on the renal function and serum levels of inflammatory factors in patients with early diabetic nephropathy.Methods:Totally 80 patients with early diabetic nephropathy were selected and randomly divided into observation group and con-trol group, with 40 patients in each group. Both groups were given conventional therapies, and the control group used Danhong injection ( TCM) additionally, while the observation group used alprostadil injection in addition to those of the control group. The levels of blood urea nitrogen ( BUN) , blood creatinine ( SCr) ,β2 microglobulin (β2-MG), 24h quantitative test for urinary protein (24h Upro), urinary albumin excretory rate ( UAER) , and serum interleukin-6 ( IL-6) , interleukin-18 ( IL-18) , tumor necrosis factor -α( TNF-α) , and hypersensitive C reactive protein ( hs-CRP ) before and after treatment were compared between the two groups. Results:Before treatment, the two groups had insignificantly different levels of BUN, SCr, 24h Upro,β2-MG, UAER and serum IL-6,IL-18,TNF-α,and hs-CRP ( P>0.05); after treatment, both groups had significantly decreased levels of BUN, SCr, 24 h Upro,β2-MG, UAER and serum IL-6, IL-18, TNF-α, and hs-CRP , but the observation group had significantly greater decreasing extents than the control group ( P<0.05) . Conclusion:Alprostadil combined with Danhong can effectively improve the renal function and de-crease the levels of inflammatory factors in patients with early diabetic nephropathy, and is highly effective and safe.关键词
前列地尔/丹红/早期糖尿病肾病/肾功能/炎性因子Key words
Alprostadil/Danhong/Early diabetic nephropathy/Renal function/Inflammatory factor引用本文复制引用
苟燕..前列地尔联合丹红对早期糖尿病肾病患者肾功能及血清炎症因子水平的影响[J].河北医学,2016,22(12):1948-1951,4.基金项目
四川省遂宁市科技计划支撑计划项目,(编号:20060231) （编号:20060231）
