河北医学2016，Vol.22Issue(12)：1951-1954,4.DOI:10.3969/j.issn.1006-6233.2016.12.006
非酒精性脂肪肝患者肾素－血管紧张素系统变化及缬沙坦胶囊对其影响的研究
The Change of Renin-angiotensin System in Patients with Nonalcoholic Fatty Liver Disease
摘要
Abstract
Objective:To investigate the nonalcoholic fatty liver ( nonalcoholic fatty liver disease, non-alcoholic fatty liver disease ( NAFLD) in plasma of patients with renin angiotensin angiotensin system ( RAS) ,and the correlation was analysed. Methods:88 patients with NAFLD were randomly collected in our hospital after the clinical related blood index and liver ultrasound and other clinical diagnosed as treatment group, and 90 healthy people were selected as control group for comparison, the treatment group were treated by Valsartan Tablets intervention treatment, were detected in the plasma of patients with the ALT, GGT, TG, TCHO, GLU, PRA, Ang I, Ang II, the data are compared, and analyze its relationship with NAFLD. Results:In the treatment group without intervention, in plasma of patients with RAS ( PRA, ang I and Ang II) , ALT, GGT and TG, TCHO, Glu and control group had a significantly increased ( P <0.05);and RAS ( PRA, ang I and Ang II) and NAFLD severity was positively correlated ( P = 0.000);treatment group after treatment and be-fore treatment compared the RAS, ALT, GGT and TG, TCHO, Glu differences were statistically significant ( P <0.05) . Conclusion:The change of plasma RAS can affect the development of NAFLD, and can improve the biochemical index of NAFLD patients, which is conducive to the improvement of the condition.关键词
非酒精性脂肪肝/肾素-血管紧张素系统/缬沙坦Key words
Nonalcoholic fatty liver disease/Renin-angiotensin system/Valsartan引用本文复制引用
丁园,李艳..非酒精性脂肪肝患者肾素－血管紧张素系统变化及缬沙坦胶囊对其影响的研究[J].河北医学,2016,22(12):1951-1954,4.基金项目
湖北省卫生厅资助课题,(编号:鄂卫发2008Y18) （编号:鄂卫发2008Y18）
