河北医学2016，Vol.22Issue(12)：1956-1959,4.DOI:10.3969/j.issn.1006-6233.2016.12.008
基础胰岛素联合二甲双胍治疗早期糖尿病周围神经病变的疗效及分子生物学机制探讨
The Efficacy and Molecular Biological Mechanism of Basal Insulin Plus Metformin for Early Diabetic Peripheral Neuropathy Patients
摘要
Abstract
Objective: To investigate the efficacy and molecular biological mechanism of basal insulin plus metformin treatment for diabetic peripheral neuropathy patients. Methods:98 cases of diabetic peripheral neuropathy were recruited and given metformin (Glucophage tablet, 0.5 bid initial) plus glargine (0.1u/kg initial) treatment adjusting to diabetic goal and lasting to12 weeks. The nerve conduction velocity of peroneal nerve, median nerve and the inflammatory factors including Leptin, Nerve growth factor, IL-6,TNF-α and NGF were tested and compared. Results:After treatment, 98 cases of early diabetic peripheral neuropathy re-sulted in blood glucose at target rate 77.6 (76/98) and total efficacy rate 81.6%(80/98). Furthermore effica-cy rate of blood glucose at target cases showed statistically difference compared to failed cases (χ2=8.407, P=0.007) . While motion and sense nerve conduction velocity of median and peroneal nerve after treatment were improved significantly compared to before ( P<0.05) . And also after the treatment inflammatory factors in ser-um including LP ( t=15.390, P=0.003) , NGF ( t=13.471 P=0.009) , IL-6 ( t=12.373, P=0.010) and TNF-α ( t=14.437, P=0.001) were decreased significantly ( P<0.05) . Conclusion:Basal insulin plus met-formin for early diabetic peripheral neuropathy could inhibit microinflammation caused by hyper glucose, im-prove diabetic peripheral nerve injuries, which should deserve further attention in clinic.关键词
糖尿病性周围神经病变/炎症因子/神经生长因子Key words
Diabetic peripheral neuropathy/Inflammatory factor/Nerve growth factor引用本文复制引用
吴刚,刘栋梁,李襄君,范小云..基础胰岛素联合二甲双胍治疗早期糖尿病周围神经病变的疗效及分子生物学机制探讨[J].河北医学,2016,22(12):1956-1959,4.基金项目
重庆市卫生科技计划项目,(编号:20130428) （编号:20130428）
