化工进展2016，Vol.35Issue(z2)：248-257,10.DOI:10.16085/j.issn.1000-6613.2016.s2.042
噻唑/唑类活性天然产物及活性小分子化合物研究进展
Advances of studies in thiazole/oxazole-based bioactive natural products and small molecules
摘要
Abstract
Thiazole/oxazole moieties in natural or artificial bioactive compounds usually biologically or biomimetically synthesized through a coupling between carboxylic groups of amino acid residues or unnatural carboxylic derivatives and natural amino acids including cysteine and serine or other artificial amino acids,followed by an oxidation or dehydrogenation,which makes C5-functionalized thiazole/oxazole moieties very rare in natural bioactive molecules.On the contrary,these moieties have commonly been seen in artificial compounds with wide and potent pharmacological activities, yet synthesis of these artificial moieties requires preparation ofβ-functionalized unnatural amino acids before the coupling and oxidation.In addition, C5-functionalizations of thiazole/oxazole-based natural products are also very rare,owing to the lack of related methodologies.These status suggest that discovering novel methodologies for the C5-functionalizations of thiazole/oxazole and applying them to the structural modification of thiazole/oxazole-based natural products will be extremely significant and valuable.关键词
噻唑/噁唑/活性天然产物/活性小分子化合物/C5位官能团化Key words
thiazole/oxazole/bioactive natural products/bioactive small molecules/C5-functionalization分类
化学化工引用本文复制引用
李瑶,李子元,王晓姣,雷搏文,赵怡,马丽芳..噻唑/唑类活性天然产物及活性小分子化合物研究进展[J].化工进展,2016,35(z2):248-257,10.基金项目
中央高校基本科研业务费项目(2016SCU11020)。 （2016SCU11020）
